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- W2004356062 abstract "The role of glial cells during different phases of multiple sclerosis (MS) is unclear. To monitor glial activation we analyzed the biomarkers YKL-40 and sCD14 in cerebrospinal fluid (CSF) from MS patients during different disease phases and in response to immunosuppressive treatment. CSF levels of YKL-40 were increased in MS during relapse, remission and secondary progression compared with healthy controls. Furthermore, YKL-40 levels in CSF decreased by mitoxantrone and natalizumab treatment. No differences were observed in CSF levels of sCD14. Thus, we can infer that glial activation is present in all MS phases and decreases by immunosuppressive treatment." @default.
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- W2004356062 date "2014-04-01" @default.
- W2004356062 modified "2023-10-13" @default.
- W2004356062 title "CSF levels of YKL-40 are increased in MS and decrease with immunosuppressive treatment" @default.
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- W2004356062 doi "https://doi.org/10.1016/j.jneuroim.2014.02.004" @default.
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