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- W2004356408 abstract "Chalcones were tested for estimating anti-aromatase, anti-3beta-hydroxysteroid dehydrogenase delta5/delta4 isomerase (3beta-HSD) and anti-17beta-hydroxysteroid dehydrogenase (17beta-HSD) activities in human placental microsomes. In the present study, we have demonstrated for the first time that chalcones are potent inhibitors of aromatase and 17beta-hydroxysteroid dehydrogenase activities: these enzymes being considered as important targets in the metabolic pathways of human mammary hormone-dependent cells. Our results showed that naringenin chalcone and 4-hydroxychalcone were the most effective aromatase and 17beta-hydroxysteroid dehydrogenase inhibitors with IC50 values of 2.6 and 16 microM respectively. In addition, inhibitory effects of some flavones and flavanones were compared to those of the corresponding chalcones. A structure-activity relationship was established and regions or/and substituents essential for these inhibitory activities were determined." @default.
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- W2004356408 date "2001-01-01" @default.
- W2004356408 modified "2023-09-23" @default.
- W2004356408 title "Chalcones are potent inhibitors of aromatase and 17β-hydroxysteroid dehydrogenase activities" @default.
- W2004356408 doi "https://doi.org/10.1016/s0024-3205(00)00974-7" @default.
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