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- W2004358512 abstract "Proarrhythmic responses to therapeutic drugs, particularly life-threatening Torsade de Pointes, is of intense interest both for clinicians and those developing and regulating drugs. Understanding the mechanisms of proarrhythmia is becoming crucially important to drug development. We discuss the major models used to elucidate mechanisms of proarrhythmia, with a focus on models that have been modified to screen drugs for proarrhythmic potential. Current controversies and future directions in modeling and preclinical screening for proarrhythmia are examined." @default.
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- W2004358512 date "2005-09-01" @default.
- W2004358512 modified "2023-10-16" @default.
- W2004358512 title "Disease models for elucidation of mechanisms and prediction of drug-induced proarrhythmia" @default.
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- W2004358512 doi "https://doi.org/10.1016/j.ddmod.2005.08.002" @default.
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