FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004364523> ?p ?o ?g. }

• W2004364523 endingPage "2523" @default.
• W2004364523 startingPage "2517" @default.
• W2004364523 abstract "During Gram-negative septic shock, lipopolysaccharide (LPS, endotoxin) induces tissue factor (TF) expression. TF expression is mediated by nuclear factor kappaB and amplified by activated platelets. TF forms a highly procoagulant complex with activated coagulation factor VII (FVIIa). Hence, we hypothesized that aspirin, which inhibits LPS-induced, nuclear factor kappaB-dependent TF expression in vitro and platelet activation in vivo, may suppress LPS-induced coagulation in humans. Therefore, we studied the effects of aspirin on systemic coagulation activation in the established and controlled setting of the human LPS model. Thirty healthy volunteers were challenged with LPS (4 ng/kg IV) after intake of either placebo or aspirin (1000 mg). Acetaminophen (1000 mg) was given to a third group to control for potential effects of antipyresis. Neither aspirin nor acetaminophen inhibited LPS-induced coagulation. However, LPS increased the percentage of circulating TF(+) monocytes by 2-fold. This increase was associated with a decrease in FVIIa levels, which reached a minimum of 50% 24 hours after LPS infusion. Furthermore, LPS-induced thrombin generation increased plasma levels of circulating polymerized, but not cross-linked, fibrin (ie, thrombus precursor protein), whereas levels of soluble fibrin were unaffected. In summary, a single 1000-mg dose of aspirin did not decrease LPS-induced coagulation. However, our study showed, for the first time, that LPS increases TF(+) monocytes, substantially decreases FVIIa levels, and enhances plasma levels of thrombus precursor protein, which may be a useful marker of fibrin formation in humans." @default.
• W2004364523 created "2016-06-24" @default.
• W2004364523 creator A5004089125 @default.
• W2004364523 creator A5005040203 @default.
• W2004364523 creator A5029196374 @default.
• W2004364523 creator A5046761476 @default.
• W2004364523 creator A5056704965 @default.
• W2004364523 creator A5056791346 @default.
• W2004364523 creator A5079920909 @default.
• W2004364523 creator A5080941679 @default.
• W2004364523 date "1999-10-01" @default.
• W2004364523 modified "2023-09-23" @default.
• W2004364523 title "Endotoxin-Induced Activation of the Coagulation Cascade in Humans" @default.
• W2004364523 cites W136849289 @default.
• W2004364523 cites W13793788 @default.
• W2004364523 cites W1582902340 @default.
• W2004364523 cites W1871651935 @default.
• W2004364523 cites W1885409055 @default.
• W2004364523 cites W1976303990 @default.
• W2004364523 cites W1994656151 @default.
• W2004364523 cites W2000421482 @default.
• W2004364523 cites W2009049327 @default.
• W2004364523 cites W2013710089 @default.
• W2004364523 cites W2056938247 @default.
• W2004364523 cites W2057016253 @default.
• W2004364523 cites W2068673334 @default.
• W2004364523 cites W2075489488 @default.
• W2004364523 cites W2125317149 @default.
• W2004364523 cites W2163604359 @default.
• W2004364523 cites W2184763690 @default.
• W2004364523 cites W2318581284 @default.
• W2004364523 cites W2336689314 @default.
• W2004364523 cites W2350813466 @default.
• W2004364523 cites W2360815100 @default.
• W2004364523 cites W2410071464 @default.
• W2004364523 cites W4230071474 @default.
• W2004364523 cites W4243155233 @default.
• W2004364523 cites W4300059719 @default.
• W2004364523 cites W4301525936 @default.
• W2004364523 cites W78534985 @default.
• W2004364523 doi "https://doi.org/10.1161/01.atv.19.10.2517" @default.
• W2004364523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10521382" @default.
• W2004364523 hasPublicationYear "1999" @default.
• W2004364523 type Work @default.
• W2004364523 sameAs 2004364523 @default.
• W2004364523 citedByCount "60" @default.
• W2004364523 countsByYear W20043645232012 @default.
• W2004364523 countsByYear W20043645232013 @default.
• W2004364523 countsByYear W20043645232015 @default.
• W2004364523 countsByYear W20043645232016 @default.
• W2004364523 countsByYear W20043645232017 @default.
• W2004364523 countsByYear W20043645232018 @default.
• W2004364523 countsByYear W20043645232019 @default.
• W2004364523 countsByYear W20043645232020 @default.
• W2004364523 countsByYear W20043645232021 @default.
• W2004364523 countsByYear W20043645232023 @default.
• W2004364523 crossrefType "journal-article" @default.
• W2004364523 hasAuthorship W2004364523A5004089125 @default.
• W2004364523 hasAuthorship W2004364523A5005040203 @default.
• W2004364523 hasAuthorship W2004364523A5029196374 @default.
• W2004364523 hasAuthorship W2004364523A5046761476 @default.
• W2004364523 hasAuthorship W2004364523A5056704965 @default.
• W2004364523 hasAuthorship W2004364523A5056791346 @default.
• W2004364523 hasAuthorship W2004364523A5079920909 @default.
• W2004364523 hasAuthorship W2004364523A5080941679 @default.
• W2004364523 hasBestOaLocation W20043645231 @default.
• W2004364523 hasConcept C126322002 @default.
• W2004364523 hasConcept C144594695 @default.
• W2004364523 hasConcept C150903083 @default.
• W2004364523 hasConcept C185592680 @default.
• W2004364523 hasConcept C186738567 @default.
• W2004364523 hasConcept C203014093 @default.
• W2004364523 hasConcept C207001950 @default.
• W2004364523 hasConcept C2777292125 @default.
• W2004364523 hasConcept C2777628954 @default.
• W2004364523 hasConcept C2778382381 @default.
• W2004364523 hasConcept C2778754761 @default.
• W2004364523 hasConcept C2781362458 @default.
• W2004364523 hasConcept C3018697912 @default.
• W2004364523 hasConcept C54173615 @default.
• W2004364523 hasConcept C55493867 @default.
• W2004364523 hasConcept C71924100 @default.
• W2004364523 hasConcept C86803240 @default.
• W2004364523 hasConcept C89560881 @default.
• W2004364523 hasConcept C98274493 @default.
• W2004364523 hasConceptScore W2004364523C126322002 @default.
• W2004364523 hasConceptScore W2004364523C144594695 @default.
• W2004364523 hasConceptScore W2004364523C150903083 @default.
• W2004364523 hasConceptScore W2004364523C185592680 @default.
• W2004364523 hasConceptScore W2004364523C186738567 @default.
• W2004364523 hasConceptScore W2004364523C203014093 @default.
• W2004364523 hasConceptScore W2004364523C207001950 @default.
• W2004364523 hasConceptScore W2004364523C2777292125 @default.
• W2004364523 hasConceptScore W2004364523C2777628954 @default.
• W2004364523 hasConceptScore W2004364523C2778382381 @default.
• W2004364523 hasConceptScore W2004364523C2778754761 @default.
• W2004364523 hasConceptScore W2004364523C2781362458 @default.
• W2004364523 hasConceptScore W2004364523C3018697912 @default.

• next