Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004366243> ?p ?o ?g. }
- W2004366243 endingPage "1410" @default.
- W2004366243 startingPage "1395" @default.
- W2004366243 abstract "Heterochromatin formation and nuclear organization are important in gene regulation and genome fidelity. Proteins involved in gene silencing localize to sites of damage and some DNA repair proteins localize to heterochromatin, but the biological importance of these correlations remains unclear. In this study, we examined the role of double-strand-break repair proteins in gene silencing and nuclear organization. We find that the ATM kinase Tel1 and the proteins Mre11 and Esc2 can silence a reporter gene dependent on the Sir, as well as on other repair proteins. Furthermore, these proteins aid in the localization of silenced domains to specific compartments in the nucleus. We identify two distinct mechanisms for repair protein–mediated silencing—via direct and indirect interactions with Sir proteins, as well as by tethering loci to the nuclear periphery. This study reveals previously unknown interactions between repair proteins and silencing proteins and suggests insights into the mechanism underlying genome integrity." @default.
- W2004366243 created "2016-06-24" @default.
- W2004366243 creator A5039221891 @default.
- W2004366243 creator A5040730065 @default.
- W2004366243 creator A5054002052 @default.
- W2004366243 creator A5058060024 @default.
- W2004366243 creator A5074298369 @default.
- W2004366243 creator A5075746413 @default.
- W2004366243 date "2015-04-01" @default.
- W2004366243 modified "2023-10-08" @default.
- W2004366243 title "Heterochromatin formation via recruitment of DNA repair proteins" @default.
- W2004366243 cites W1518422217 @default.
- W2004366243 cites W1536757970 @default.
- W2004366243 cites W1567934333 @default.
- W2004366243 cites W1667638673 @default.
- W2004366243 cites W168838647 @default.
- W2004366243 cites W1963512031 @default.
- W2004366243 cites W1966900987 @default.
- W2004366243 cites W1968002116 @default.
- W2004366243 cites W1968945962 @default.
- W2004366243 cites W1971187054 @default.
- W2004366243 cites W1971227936 @default.
- W2004366243 cites W1971419576 @default.
- W2004366243 cites W1972416435 @default.
- W2004366243 cites W1974131162 @default.
- W2004366243 cites W1975394594 @default.
- W2004366243 cites W1976939918 @default.
- W2004366243 cites W1978809012 @default.
- W2004366243 cites W1982134344 @default.
- W2004366243 cites W1983051197 @default.
- W2004366243 cites W1983555324 @default.
- W2004366243 cites W1983982473 @default.
- W2004366243 cites W1985544638 @default.
- W2004366243 cites W1989891368 @default.
- W2004366243 cites W1990778506 @default.
- W2004366243 cites W2000098053 @default.
- W2004366243 cites W2004257622 @default.
- W2004366243 cites W2004593059 @default.
- W2004366243 cites W2006860216 @default.
- W2004366243 cites W2013158844 @default.
- W2004366243 cites W2018950379 @default.
- W2004366243 cites W2019311548 @default.
- W2004366243 cites W2025268136 @default.
- W2004366243 cites W2027802256 @default.
- W2004366243 cites W2030776068 @default.
- W2004366243 cites W2030829729 @default.
- W2004366243 cites W2031098287 @default.
- W2004366243 cites W2034564804 @default.
- W2004366243 cites W2036477200 @default.
- W2004366243 cites W2036546456 @default.
- W2004366243 cites W2041065032 @default.
- W2004366243 cites W2041731996 @default.
- W2004366243 cites W2043689293 @default.
- W2004366243 cites W2044514589 @default.
- W2004366243 cites W2044904363 @default.
- W2004366243 cites W2045090702 @default.
- W2004366243 cites W2045390356 @default.
- W2004366243 cites W2051193631 @default.
- W2004366243 cites W2057072455 @default.
- W2004366243 cites W2058223290 @default.
- W2004366243 cites W2059548561 @default.
- W2004366243 cites W2061806029 @default.
- W2004366243 cites W2065858253 @default.
- W2004366243 cites W2067328670 @default.
- W2004366243 cites W2067539799 @default.
- W2004366243 cites W2067800090 @default.
- W2004366243 cites W2072727544 @default.
- W2004366243 cites W2073457890 @default.
- W2004366243 cites W2073869348 @default.
- W2004366243 cites W2077705447 @default.
- W2004366243 cites W2081608088 @default.
- W2004366243 cites W2081702399 @default.
- W2004366243 cites W2085060332 @default.
- W2004366243 cites W2085461478 @default.
- W2004366243 cites W2087210621 @default.
- W2004366243 cites W2087957210 @default.
- W2004366243 cites W2089273749 @default.
- W2004366243 cites W2093531054 @default.
- W2004366243 cites W2096286842 @default.
- W2004366243 cites W2097530046 @default.
- W2004366243 cites W2097982583 @default.
- W2004366243 cites W2102155883 @default.
- W2004366243 cites W2102604046 @default.
- W2004366243 cites W2105487944 @default.
- W2004366243 cites W2106680800 @default.
- W2004366243 cites W2106795964 @default.
- W2004366243 cites W2107835389 @default.
- W2004366243 cites W2108484316 @default.
- W2004366243 cites W2109115348 @default.
- W2004366243 cites W2111217339 @default.
- W2004366243 cites W2113051223 @default.
- W2004366243 cites W2114099572 @default.
- W2004366243 cites W2116202869 @default.
- W2004366243 cites W2116636376 @default.
- W2004366243 cites W2117019939 @default.
- W2004366243 cites W2117502397 @default.
- W2004366243 cites W2117541842 @default.
- W2004366243 cites W2118785964 @default.