FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004367631> ?p ?o ?g. }

• W2004367631 endingPage "59" @default.
• W2004367631 startingPage "49" @default.
• W2004367631 abstract "Nano-scale zinc oxide (nano-ZnO) is widely used in various industrial and commercial applications. However, the available toxicological information was inadequate to assess the potential ecological risk of nano-ZnO to aquatic organisms and the publics. In this study, the developmental toxicity, oxidative stress and DNA damage of nano-ZnO embryos were investigated in the embryo-larval zebrafish, the toxicity of Zn(2+) releasing from nano-ZnO were also investigated to ascertain the relationship between the nano-ZnO and corresponding Zn(2+). Zebrafish embryos were exposed to 1, 5, 10, 20, 50, and 100mg/L nano-ZnO and 0.59, 2.15, 3.63, 4.07, 5.31, and 6.04 mg/L Zn(2+) for 144 h post-fertilisation (hpf), respectively. Up to 144 hpf, activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and malondialdehyde (MDA) contents, the genes related to oxidative damage, reactive oxygen species (ROS) generation and DNA damage in zebrafish embryos were measured. The nano-ZnO was found to exert a dose-dependent toxicity to zebrafish embryos and larvae, reducing the hatching rate and inducing malformation and the acute toxicity to zebrafish embryos was greater than that of the Zn(2+) solution. The generation of ROS was significantly increased at 50 and 100mg/L nano-ZnO. DNA damage of zebrafish embryo was evaluated by single-cell gel electrophoresis and was enhanced with increasing nano-ZnO concentration. Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Bcl-2, in response to oxidative damage, such as Nqo1, and related to antioxidant response element such as Gstp2 were significantly down-regulated in the nano-ZnO treatment groups. However, the nano-ZnO up-regulated the transcriptional expression of Ucp2-related to ROS production. In conclusion, nano-ZnO induces developmental toxicity, oxidative stress and DNA damage on zebrafish embryos and the dissolved Zn(2+) only partially contributed to the toxicity of nano-ZnO. The adverse effects of nano-ZnO may be the important mechanisms of its toxicity to zebrafish embryos." @default.
• W2004367631 created "2016-06-24" @default.
• W2004367631 creator A5010090660 @default.
• W2004367631 creator A5026884311 @default.
• W2004367631 creator A5045502057 @default.
• W2004367631 creator A5071026407 @default.
• W2004367631 creator A5076607259 @default.
• W2004367631 date "2013-07-01" @default.
• W2004367631 modified "2023-10-14" @default.
• W2004367631 title "Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish" @default.
• W2004367631 cites W1539347645 @default.
• W2004367631 cites W1964123007 @default.
• W2004367631 cites W1967133409 @default.
• W2004367631 cites W1974465665 @default.
• W2004367631 cites W1980230824 @default.
• W2004367631 cites W1983363026 @default.
• W2004367631 cites W1986492157 @default.
• W2004367631 cites W1986798142 @default.
• W2004367631 cites W1990075727 @default.
• W2004367631 cites W1998656352 @default.
• W2004367631 cites W2007792678 @default.
• W2004367631 cites W2011176452 @default.
• W2004367631 cites W2011424097 @default.
• W2004367631 cites W2013556000 @default.
• W2004367631 cites W2019387766 @default.
• W2004367631 cites W2021534535 @default.
• W2004367631 cites W2034173353 @default.
• W2004367631 cites W2049711416 @default.
• W2004367631 cites W2053471764 @default.
• W2004367631 cites W2060354063 @default.
• W2004367631 cites W2062430935 @default.
• W2004367631 cites W2064045607 @default.
• W2004367631 cites W2070224069 @default.
• W2004367631 cites W2071137645 @default.
• W2004367631 cites W2071895889 @default.
• W2004367631 cites W2073404756 @default.
• W2004367631 cites W2074945181 @default.
• W2004367631 cites W2076664843 @default.
• W2004367631 cites W2082102612 @default.
• W2004367631 cites W2085404072 @default.
• W2004367631 cites W2090412969 @default.
• W2004367631 cites W2107277218 @default.
• W2004367631 cites W2132411546 @default.
• W2004367631 cites W2138573825 @default.
• W2004367631 cites W2154140763 @default.
• W2004367631 cites W2158464982 @default.
• W2004367631 cites W2160890470 @default.
• W2004367631 cites W2168059777 @default.
• W2004367631 cites W3021181849 @default.
• W2004367631 cites W4293247451 @default.
• W2004367631 cites W969915667 @default.
• W2004367631 doi "https://doi.org/10.1016/j.aquatox.2013.03.019" @default.
• W2004367631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23643724" @default.
• W2004367631 hasPublicationYear "2013" @default.
• W2004367631 type Work @default.
• W2004367631 sameAs 2004367631 @default.
• W2004367631 citedByCount "277" @default.
• W2004367631 countsByYear W20043676312013 @default.
• W2004367631 countsByYear W20043676312014 @default.
• W2004367631 countsByYear W20043676312015 @default.
• W2004367631 countsByYear W20043676312016 @default.
• W2004367631 countsByYear W20043676312017 @default.
• W2004367631 countsByYear W20043676312018 @default.
• W2004367631 countsByYear W20043676312019 @default.
• W2004367631 countsByYear W20043676312020 @default.
• W2004367631 countsByYear W20043676312021 @default.
• W2004367631 countsByYear W20043676312022 @default.
• W2004367631 countsByYear W20043676312023 @default.
• W2004367631 crossrefType "journal-article" @default.
• W2004367631 hasAuthorship W2004367631A5010090660 @default.
• W2004367631 hasAuthorship W2004367631A5026884311 @default.
• W2004367631 hasAuthorship W2004367631A5045502057 @default.
• W2004367631 hasAuthorship W2004367631A5071026407 @default.
• W2004367631 hasAuthorship W2004367631A5076607259 @default.
• W2004367631 hasConcept C104317684 @default.
• W2004367631 hasConcept C143425029 @default.
• W2004367631 hasConcept C153911025 @default.
• W2004367631 hasConcept C178790620 @default.
• W2004367631 hasConcept C179335377 @default.
• W2004367631 hasConcept C181199279 @default.
• W2004367631 hasConcept C185592680 @default.
• W2004367631 hasConcept C196843134 @default.
• W2004367631 hasConcept C2775838275 @default.
• W2004367631 hasConcept C2776151105 @default.
• W2004367631 hasConcept C2776878037 @default.
• W2004367631 hasConcept C2778401633 @default.
• W2004367631 hasConcept C2778760513 @default.
• W2004367631 hasConcept C2778979269 @default.
• W2004367631 hasConcept C2779234561 @default.
• W2004367631 hasConcept C29730261 @default.
• W2004367631 hasConcept C46973012 @default.
• W2004367631 hasConcept C48349386 @default.
• W2004367631 hasConcept C538909803 @default.
• W2004367631 hasConcept C54355233 @default.
• W2004367631 hasConcept C552990157 @default.
• W2004367631 hasConcept C55493867 @default.
• W2004367631 hasConcept C86803240 @default.
• W2004367631 hasConcept C95444343 @default.

• next