FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004367892> ?p ?o ?g. }

• W2004367892 endingPage "969" @default.
• W2004367892 startingPage "969" @default.
• W2004367892 abstract "<h3>Context</h3> Recent magnetic resonance imaging studies have attempted to relate volumetric brain measurements in early schizophrenia to clinical and functional outcome some years later. These studies have generally been negative, perhaps because gray and white matter volumes inaccurately assess the underlying dysfunction that might be predictive of outcome. <h3>Objective</h3> To investigate the predictive value of frontal and temporal spectroscopy measures for outcome in patients with first-episode psychoses. <h3>Design</h3> Left prefrontal cortex and left mediotemporal lobe voxels were assessed using proton magnetic resonance spectroscopy to provide the ratio of<i>N</i>-acetylaspartate (NAA) and choline-containing compounds to creatine and phosphocreatine (Cr) (NAA/Cr ratio). These data were used to predict outcome at 18 months after admission, as assessed by a systematic medical record audit. <h3>Setting</h3> Early psychosis clinic. <h3>Participants</h3> Forty-six patients with first-episode psychosis. <h3>Main Outcome Measures</h3> We used regression models that included age at imaging and duration of untreated psychosis to predict outcome scores on the Global Assessment of Functioning Scale, Clinical Global Impression scales, and Social and Occupational Functional Assessment Scale, as well as the number of admissions during the treatment period. We then further considered the contributions of premorbid function and baseline level of negative symptoms. <h3>Results</h3> The only spectroscopic predictor of outcome was the NAA/Cr ratio in the prefrontal cortex. Low scores on this variable were related to poorer outcome on all measures. In addition, the frontal NAA/Cr ratio explained 17% to 30% of the variance in outcome. <h3>Conclusions</h3> Prefrontal neuronal dysfunction is an inconsistent feature of early psychosis; rather, it is an early marker of poor prognosis across the first years of illness. The extent to which this can be used to guide treatment and whether it predicts outcome some years after first presentation are questions for further research." @default.
• W2004367892 created "2016-06-24" @default.
• W2004367892 creator A5011264157 @default.
• W2004367892 creator A5013735872 @default.
• W2004367892 creator A5017123409 @default.
• W2004367892 creator A5027421232 @default.
• W2004367892 creator A5038211666 @default.
• W2004367892 creator A5049310035 @default.
• W2004367892 creator A5058238831 @default.
• W2004367892 creator A5059823463 @default.
• W2004367892 creator A5059967833 @default.
• W2004367892 date "2006-09-01" @default.
• W2004367892 modified "2023-10-16" @default.
• W2004367892 title "Prediction of Functional Outcome 18 Months After a First Psychotic Episode" @default.
• W2004367892 cites W1514552878 @default.
• W2004367892 cites W1583604396 @default.
• W2004367892 cites W1745420251 @default.
• W2004367892 cites W1922984638 @default.
• W2004367892 cites W1963015295 @default.
• W2004367892 cites W1966744247 @default.
• W2004367892 cites W1978251978 @default.
• W2004367892 cites W1979926207 @default.
• W2004367892 cites W1981230297 @default.
• W2004367892 cites W1983689355 @default.
• W2004367892 cites W1984763197 @default.
• W2004367892 cites W1985994929 @default.
• W2004367892 cites W1991553949 @default.
• W2004367892 cites W2000552729 @default.
• W2004367892 cites W2001515160 @default.
• W2004367892 cites W2002227725 @default.
• W2004367892 cites W2005569406 @default.
• W2004367892 cites W2005689612 @default.
• W2004367892 cites W2005991321 @default.
• W2004367892 cites W2014316843 @default.
• W2004367892 cites W2015095970 @default.
• W2004367892 cites W2016008469 @default.
• W2004367892 cites W2019875845 @default.
• W2004367892 cites W2020844317 @default.
• W2004367892 cites W2022378867 @default.
• W2004367892 cites W2026035034 @default.
• W2004367892 cites W2030034545 @default.
• W2004367892 cites W2030496540 @default.
• W2004367892 cites W2038979894 @default.
• W2004367892 cites W2041713747 @default.
• W2004367892 cites W2042140307 @default.
• W2004367892 cites W2044453219 @default.
• W2004367892 cites W2048187664 @default.
• W2004367892 cites W2049725422 @default.
• W2004367892 cites W2056132514 @default.
• W2004367892 cites W2064163179 @default.
• W2004367892 cites W2069533264 @default.
• W2004367892 cites W2081391357 @default.
• W2004367892 cites W2083585474 @default.
• W2004367892 cites W2088772672 @default.
• W2004367892 cites W2091584492 @default.
• W2004367892 cites W2096402599 @default.
• W2004367892 cites W2096824069 @default.
• W2004367892 cites W2098644261 @default.
• W2004367892 cites W2100173716 @default.
• W2004367892 cites W2100728134 @default.
• W2004367892 cites W2105115268 @default.
• W2004367892 cites W2112090350 @default.
• W2004367892 cites W2112252233 @default.
• W2004367892 cites W2114694690 @default.
• W2004367892 cites W2116342892 @default.
• W2004367892 cites W2120300760 @default.
• W2004367892 cites W2123684395 @default.
• W2004367892 cites W2127679160 @default.
• W2004367892 cites W2129863218 @default.
• W2004367892 cites W2131174789 @default.
• W2004367892 cites W2131635913 @default.
• W2004367892 cites W2132406375 @default.
• W2004367892 cites W2134262474 @default.
• W2004367892 cites W2135408016 @default.
• W2004367892 cites W2138096904 @default.
• W2004367892 cites W2140606211 @default.
• W2004367892 cites W2142489364 @default.
• W2004367892 cites W2143464284 @default.
• W2004367892 cites W2145240519 @default.
• W2004367892 cites W2145453003 @default.
• W2004367892 cites W2154849243 @default.
• W2004367892 cites W2155682492 @default.
• W2004367892 cites W2156123885 @default.
• W2004367892 cites W2156964024 @default.
• W2004367892 cites W2157578878 @default.
• W2004367892 cites W2168850239 @default.
• W2004367892 cites W2245923556 @default.
• W2004367892 cites W2284323937 @default.
• W2004367892 cites W2288873596 @default.
• W2004367892 cites W2520244658 @default.
• W2004367892 cites W279136605 @default.
• W2004367892 cites W2798177004 @default.
• W2004367892 cites W3090293687 @default.
• W2004367892 doi "https://doi.org/10.1001/archpsyc.63.9.969" @default.
• W2004367892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16952999" @default.
• W2004367892 hasPublicationYear "2006" @default.
• W2004367892 type Work @default.
• W2004367892 sameAs 2004367892 @default.

• next