FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004367933> ?p ?o ?g. }

• W2004367933 endingPage "333" @default.
• W2004367933 startingPage "322" @default.
• W2004367933 abstract "P38/Mk2 (mitogen-activated protein kinase (MAPK)-activated protein kinase-2, also known as MAKAP kinase-2) is a member of the mitogen-activated protein kinases (MAPKs) family, and participates in inflammatory responses directly or indirectly. WIN55, 212-2 (WIN55) is a synthetic non-selective agonist of cannabinoid (CB) receptors with remarkable anti-inflammatory properties. This study was to explore the roles of WIN55 and p38/Mk2 signaling pathway in dextran sodium sulfate (DSS)-induced mouse colitis and ascertain their anti-inflammatory mechanisms. Colitis was induced in C57BL Mk2 gene homozygous deletion (Mk2−/−) and wild-type mice by replacing the drinking water with 4% DSS solution for 7 days. DSS-treated mice developed bloody stool, weight loss, and eye-visible multiple bleeding ulcers on colon mucosa. The mRNA expressions levels of TNF-α and IL-6, as well as the protein levels of p38 and its phosphorylated form (p-p38), were upregulated in the colon. The plasma levels of TNF-α, IL-6, cytokine-induced neutrophil chemoattractant-1 (CINC-1), monocyte chemoattractant protein-1 (MCP-1), and lung myeloperoxidase (MPO) activities were raised; however, all these changes were less severe in Mk2−/− mice. After WIN55 intervention, the Mk2−/− mice recovered faster and better from the induced colitis than their wild-type counterparts. The results indicate that the Mk2 homozygous deletion in mice impedes the induction of experimental colitis by DSS, confirming the notion that p38/Mk2 is involved in this inflammatory response. WIN55 protects mice against DSS-induced colitis, in particular when the p38/Mk2 pathway is obstructed, implying that the activation of CB system, together with blocking of p38/Mk2 pathway, serves as a potential drug target for colitis treatment." @default.
• W2004367933 created "2016-06-24" @default.
• W2004367933 creator A5000112970 @default.
• W2004367933 creator A5022518166 @default.
• W2004367933 creator A5024672834 @default.
• W2004367933 creator A5029099268 @default.
• W2004367933 creator A5039603875 @default.
• W2004367933 creator A5042739930 @default.
• W2004367933 creator A5049988648 @default.
• W2004367933 creator A5051824914 @default.
• W2004367933 creator A5052276729 @default.
• W2004367933 creator A5069421991 @default.
• W2004367933 creator A5082295029 @default.
• W2004367933 date "2013-03-01" @default.
• W2004367933 modified "2023-10-15" @default.
• W2004367933 title "Inhibition of p38/Mk2 signaling pathway improves the anti-inflammatory effect of WIN55 on mouse experimental colitis" @default.
• W2004367933 cites W143990354 @default.
• W2004367933 cites W1549461333 @default.
• W2004367933 cites W1963614756 @default.
• W2004367933 cites W1964856587 @default.
• W2004367933 cites W1969630749 @default.
• W2004367933 cites W1974249296 @default.
• W2004367933 cites W1979948289 @default.
• W2004367933 cites W1983512753 @default.
• W2004367933 cites W1984050494 @default.
• W2004367933 cites W1995788380 @default.
• W2004367933 cites W1996405087 @default.
• W2004367933 cites W1997761130 @default.
• W2004367933 cites W2005177957 @default.
• W2004367933 cites W2013686136 @default.
• W2004367933 cites W2030928098 @default.
• W2004367933 cites W2032089087 @default.
• W2004367933 cites W2032160537 @default.
• W2004367933 cites W2051554315 @default.
• W2004367933 cites W2057447694 @default.
• W2004367933 cites W2062086000 @default.
• W2004367933 cites W2064987082 @default.
• W2004367933 cites W2068392219 @default.
• W2004367933 cites W2073782166 @default.
• W2004367933 cites W2075894678 @default.
• W2004367933 cites W2076012365 @default.
• W2004367933 cites W2077511764 @default.
• W2004367933 cites W2077885793 @default.
• W2004367933 cites W2078541372 @default.
• W2004367933 cites W2086655427 @default.
• W2004367933 cites W2089935502 @default.
• W2004367933 cites W2093515294 @default.
• W2004367933 cites W2097780835 @default.
• W2004367933 cites W2106591690 @default.
• W2004367933 cites W2123531867 @default.
• W2004367933 cites W2127551467 @default.
• W2004367933 cites W2133012380 @default.
• W2004367933 cites W2136160086 @default.
• W2004367933 cites W2152803022 @default.
• W2004367933 cites W2157518435 @default.
• W2004367933 cites W2160320629 @default.
• W2004367933 cites W2167986140 @default.
• W2004367933 cites W2171841010 @default.
• W2004367933 cites W4254752226 @default.
• W2004367933 cites W4294216491 @default.
• W2004367933 cites W9714344 @default.
• W2004367933 doi "https://doi.org/10.1038/labinvest.2012.177" @default.
• W2004367933 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23381627" @default.
• W2004367933 hasPublicationYear "2013" @default.
• W2004367933 type Work @default.
• W2004367933 sameAs 2004367933 @default.
• W2004367933 citedByCount "32" @default.
• W2004367933 countsByYear W20043679332013 @default.
• W2004367933 countsByYear W20043679332014 @default.
• W2004367933 countsByYear W20043679332016 @default.
• W2004367933 countsByYear W20043679332017 @default.
• W2004367933 countsByYear W20043679332018 @default.
• W2004367933 countsByYear W20043679332019 @default.
• W2004367933 countsByYear W20043679332020 @default.
• W2004367933 countsByYear W20043679332021 @default.
• W2004367933 countsByYear W20043679332022 @default.
• W2004367933 countsByYear W20043679332023 @default.
• W2004367933 crossrefType "journal-article" @default.
• W2004367933 hasAuthorship W2004367933A5000112970 @default.
• W2004367933 hasAuthorship W2004367933A5022518166 @default.
• W2004367933 hasAuthorship W2004367933A5024672834 @default.
• W2004367933 hasAuthorship W2004367933A5029099268 @default.
• W2004367933 hasAuthorship W2004367933A5039603875 @default.
• W2004367933 hasAuthorship W2004367933A5042739930 @default.
• W2004367933 hasAuthorship W2004367933A5049988648 @default.
• W2004367933 hasAuthorship W2004367933A5051824914 @default.
• W2004367933 hasAuthorship W2004367933A5052276729 @default.
• W2004367933 hasAuthorship W2004367933A5069421991 @default.
• W2004367933 hasAuthorship W2004367933A5082295029 @default.
• W2004367933 hasBestOaLocation W20043679331 @default.
• W2004367933 hasConcept C134018914 @default.
• W2004367933 hasConcept C184235292 @default.
• W2004367933 hasConcept C185592680 @default.
• W2004367933 hasConcept C203014093 @default.
• W2004367933 hasConcept C203565725 @default.
• W2004367933 hasConcept C2775862500 @default.
• W2004367933 hasConcept C2776914184 @default.
• W2004367933 hasConcept C51551487 @default.

• next