Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004368046> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2004368046 abstract "The chick embryotoxicity screening test (CHEST) and the Salmonella/microsome bioassay were used to evaluate embryotoxic and mutagenic endpoints from crude coal tar (CT) and its fractionated polycyclic aromatic hydrocarbon (PAH) mixtures (designated as A, B, C, D and E). In the CHEST assay, CT and PAH mixtures were injected into the egg yolk. A dose-dependent increase in embryo mortality was observed for all fractions. The E fraction resulted in 47% embryo mortality at a dose of 0.125 mg/kg and was more toxic than CT. At a dose of 1 mg/kg, 85-100% embryonic deaths occurred in fractions C and D and these two fractions were more potent than fractions A and B. The main visual toxic manifestations were liver lesions, discoloration of the liver, and edema. Both CT and fractionated PAH mixtures were also tested in the Salmonella/microsome plate incorporation assay with Salmonella typhimurium strain TA98 and were evaluated with and without metabolic activation at five dose levels. In the presence of S9, the CT and fractions C, D and E induced a dose-dependent positive response. Results from the Salmonella/microsome assay were in good agreement with findings from the CHEST assay suggesting that these two bioassays in combination may facilitate the rapid detection and ranking of complex PAH mixtures." @default.
- W2004368046 created "2016-06-24" @default.
- W2004368046 creator A5003998604 @default.
- W2004368046 creator A5005926701 @default.
- W2004368046 creator A5007368552 @default.
- W2004368046 creator A5010389984 @default.
- W2004368046 creator A5027628494 @default.
- W2004368046 creator A5050285480 @default.
- W2004368046 creator A5066163451 @default.
- W2004368046 date "1999-04-01" @default.
- W2004368046 modified "2023-09-26" @default.
- W2004368046 title "Multi-bioassay approach for assessing the potency of complex mixtures of polycyclic aromatic hydrocarbons" @default.
- W2004368046 cites W1533937971 @default.
- W2004368046 cites W1973195696 @default.
- W2004368046 cites W1982514822 @default.
- W2004368046 cites W2005156172 @default.
- W2004368046 cites W2013261270 @default.
- W2004368046 cites W2013807142 @default.
- W2004368046 cites W2034977271 @default.
- W2004368046 cites W2037850796 @default.
- W2004368046 cites W2044700222 @default.
- W2004368046 cites W2048996333 @default.
- W2004368046 cites W2050344830 @default.
- W2004368046 cites W2054793758 @default.
- W2004368046 cites W2058239897 @default.
- W2004368046 cites W2073740171 @default.
- W2004368046 cites W2074593677 @default.
- W2004368046 cites W2090785161 @default.
- W2004368046 cites W2141301242 @default.
- W2004368046 cites W2466903987 @default.
- W2004368046 doi "https://doi.org/10.1016/s0045-6535(98)00389-0" @default.
- W2004368046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10101844" @default.
- W2004368046 hasPublicationYear "1999" @default.
- W2004368046 type Work @default.
- W2004368046 sameAs 2004368046 @default.
- W2004368046 citedByCount "10" @default.
- W2004368046 countsByYear W20043680462016 @default.
- W2004368046 countsByYear W20043680462017 @default.
- W2004368046 crossrefType "journal-article" @default.
- W2004368046 hasAuthorship W2004368046A5003998604 @default.
- W2004368046 hasAuthorship W2004368046A5005926701 @default.
- W2004368046 hasAuthorship W2004368046A5007368552 @default.
- W2004368046 hasAuthorship W2004368046A5010389984 @default.
- W2004368046 hasAuthorship W2004368046A5027628494 @default.
- W2004368046 hasAuthorship W2004368046A5050285480 @default.
- W2004368046 hasAuthorship W2004368046A5066163451 @default.
- W2004368046 hasConcept C104488531 @default.
- W2004368046 hasConcept C107872376 @default.
- W2004368046 hasConcept C178790620 @default.
- W2004368046 hasConcept C185592680 @default.
- W2004368046 hasConcept C202751555 @default.
- W2004368046 hasConcept C2776678776 @default.
- W2004368046 hasConcept C2779033964 @default.
- W2004368046 hasConcept C2779554610 @default.
- W2004368046 hasConcept C2781065037 @default.
- W2004368046 hasConcept C29730261 @default.
- W2004368046 hasConcept C33070731 @default.
- W2004368046 hasConcept C43617362 @default.
- W2004368046 hasConcept C518851703 @default.
- W2004368046 hasConcept C523546767 @default.
- W2004368046 hasConcept C54355233 @default.
- W2004368046 hasConcept C55493867 @default.
- W2004368046 hasConcept C86803240 @default.
- W2004368046 hasConcept C87644729 @default.
- W2004368046 hasConceptScore W2004368046C104488531 @default.
- W2004368046 hasConceptScore W2004368046C107872376 @default.
- W2004368046 hasConceptScore W2004368046C178790620 @default.
- W2004368046 hasConceptScore W2004368046C185592680 @default.
- W2004368046 hasConceptScore W2004368046C202751555 @default.
- W2004368046 hasConceptScore W2004368046C2776678776 @default.
- W2004368046 hasConceptScore W2004368046C2779033964 @default.
- W2004368046 hasConceptScore W2004368046C2779554610 @default.
- W2004368046 hasConceptScore W2004368046C2781065037 @default.
- W2004368046 hasConceptScore W2004368046C29730261 @default.
- W2004368046 hasConceptScore W2004368046C33070731 @default.
- W2004368046 hasConceptScore W2004368046C43617362 @default.
- W2004368046 hasConceptScore W2004368046C518851703 @default.
- W2004368046 hasConceptScore W2004368046C523546767 @default.
- W2004368046 hasConceptScore W2004368046C54355233 @default.
- W2004368046 hasConceptScore W2004368046C55493867 @default.
- W2004368046 hasConceptScore W2004368046C86803240 @default.
- W2004368046 hasConceptScore W2004368046C87644729 @default.
- W2004368046 hasLocation W20043680461 @default.
- W2004368046 hasLocation W20043680462 @default.
- W2004368046 hasOpenAccess W2004368046 @default.
- W2004368046 hasPrimaryLocation W20043680461 @default.
- W2004368046 hasRelatedWork W1963886723 @default.
- W2004368046 hasRelatedWork W2000469111 @default.
- W2004368046 hasRelatedWork W2002287733 @default.
- W2004368046 hasRelatedWork W2004368046 @default.
- W2004368046 hasRelatedWork W2044410425 @default.
- W2004368046 hasRelatedWork W2074240810 @default.
- W2004368046 hasRelatedWork W2123739314 @default.
- W2004368046 hasRelatedWork W2404154448 @default.
- W2004368046 hasRelatedWork W2411615688 @default.
- W2004368046 hasRelatedWork W3212601079 @default.
- W2004368046 isParatext "false" @default.
- W2004368046 isRetracted "false" @default.
- W2004368046 magId "2004368046" @default.
- W2004368046 workType "article" @default.