FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004368602> ?p ?o ?g. }

• W2004368602 endingPage "951" @default.
• W2004368602 startingPage "944" @default.
• W2004368602 abstract "Abstract: The effects of status epilepticus on the concentration, synthesis, release, and subcellular localization of acetylcholine, the concentration of choline, and the activity of acetylcholinesterase in rat brain regions were studied. Generalized convulsive status epilepticus was induced by the administration of pilocarpine to lithium‐treated rats. The concentration of acetylcholine in the cortex, hippocampus, and striatum decreased prior to the onset of spike activity or status epilepticus. Once status epilepticus began, the concentration of acetylcholine increased over time in the cortex and hippocampus, reaching peak levels that were 461% and 304% of control levels, respectively, after 2 h of seizures. Such high in vivo levels of acetylcholine had not been reported previously following any treatment. During status epilepticus, the concentration of acetylcholine in the striatum returned to control levels after the initial depression, but did not accumulate to high levels as it did in the other two regions. The in vivo cortical efflux of acetylcholine was also increased during the seizures. Choline levels were increased by status epilepticus in all three brain regions. Inhibition of seizures by pretreatment with atropine blocked the increases of acetylcholine and choline. Synaptosomes prepared from the cortex and from the hippocampus of rats with status epilepticus had elevated concentrations of acetylcholine: in the hippocampus the acetylcholine was principally in the cytoplasmic fraction, whereas in the cortex the acetylcholine was elevated in both the cytoplasmic and the vesicular fractions. The extra acetylcholine was in a releasable compartment, since increased K + in the media or ouabain increased the release of acetylcholine from cortical slices to a greater extent in tissue from seized rats than from controls. The activity of acetylcholinesterase was not reduced by status epilepticus. These findings demonstrate that status epilepticus induced by lithium and pilocarpine alters the regulation of acetylcholine synthesis." @default.
• W2004368602 created "2016-06-24" @default.
• W2004368602 creator A5037199856 @default.
• W2004368602 creator A5039256755 @default.
• W2004368602 creator A5089737043 @default.
• W2004368602 date "1987-09-01" @default.
• W2004368602 modified "2023-10-16" @default.
• W2004368602 title "Acetylcholine Content in Rat Brain Is Elevated by Status Epilepticus Induced by Lithium and Pilocarpine" @default.
• W2004368602 cites W1568239579 @default.
• W2004368602 cites W1967423426 @default.
• W2004368602 cites W1971048984 @default.
• W2004368602 cites W1971181432 @default.
• W2004368602 cites W1972813157 @default.
• W2004368602 cites W1976260728 @default.
• W2004368602 cites W1978644659 @default.
• W2004368602 cites W1988240074 @default.
• W2004368602 cites W2000515843 @default.
• W2004368602 cites W2002175811 @default.
• W2004368602 cites W2009304543 @default.
• W2004368602 cites W2014440543 @default.
• W2004368602 cites W2015776993 @default.
• W2004368602 cites W2020861565 @default.
• W2004368602 cites W2024546352 @default.
• W2004368602 cites W2029073753 @default.
• W2004368602 cites W2038520149 @default.
• W2004368602 cites W2043765423 @default.
• W2004368602 cites W2044426353 @default.
• W2004368602 cites W2050625418 @default.
• W2004368602 cites W2053789595 @default.
• W2004368602 cites W2054231197 @default.
• W2004368602 cites W2056272943 @default.
• W2004368602 cites W2060295599 @default.
• W2004368602 cites W2061374977 @default.
• W2004368602 cites W2071789460 @default.
• W2004368602 cites W2075887314 @default.
• W2004368602 cites W2090283974 @default.
• W2004368602 cites W2093413350 @default.
• W2004368602 cites W2139926641 @default.
• W2004368602 doi "https://doi.org/10.1111/j.1471-4159.1987.tb00985.x" @default.
• W2004368602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3612132" @default.
• W2004368602 hasPublicationYear "1987" @default.
• W2004368602 type Work @default.
• W2004368602 sameAs 2004368602 @default.
• W2004368602 citedByCount "76" @default.
• W2004368602 countsByYear W20043686022013 @default.
• W2004368602 countsByYear W20043686022014 @default.
• W2004368602 countsByYear W20043686022015 @default.
• W2004368602 countsByYear W20043686022016 @default.
• W2004368602 countsByYear W20043686022017 @default.
• W2004368602 countsByYear W20043686022018 @default.
• W2004368602 countsByYear W20043686022019 @default.
• W2004368602 countsByYear W20043686022020 @default.
• W2004368602 crossrefType "journal-article" @default.
• W2004368602 hasAuthorship W2004368602A5037199856 @default.
• W2004368602 hasAuthorship W2004368602A5039256755 @default.
• W2004368602 hasAuthorship W2004368602A5089737043 @default.
• W2004368602 hasConcept C126322002 @default.
• W2004368602 hasConcept C134018914 @default.
• W2004368602 hasConcept C169760540 @default.
• W2004368602 hasConcept C170493617 @default.
• W2004368602 hasConcept C185592680 @default.
• W2004368602 hasConcept C2775910092 @default.
• W2004368602 hasConcept C2777204577 @default.
• W2004368602 hasConcept C2777341932 @default.
• W2004368602 hasConcept C2778186239 @default.
• W2004368602 hasConcept C2780062018 @default.
• W2004368602 hasConcept C2781123555 @default.
• W2004368602 hasConcept C2781161787 @default.
• W2004368602 hasConcept C33789571 @default.
• W2004368602 hasConcept C513476851 @default.
• W2004368602 hasConcept C55493867 @default.
• W2004368602 hasConcept C71924100 @default.
• W2004368602 hasConcept C86803240 @default.
• W2004368602 hasConceptScore W2004368602C126322002 @default.
• W2004368602 hasConceptScore W2004368602C134018914 @default.
• W2004368602 hasConceptScore W2004368602C169760540 @default.
• W2004368602 hasConceptScore W2004368602C170493617 @default.
• W2004368602 hasConceptScore W2004368602C185592680 @default.
• W2004368602 hasConceptScore W2004368602C2775910092 @default.
• W2004368602 hasConceptScore W2004368602C2777204577 @default.
• W2004368602 hasConceptScore W2004368602C2777341932 @default.
• W2004368602 hasConceptScore W2004368602C2778186239 @default.
• W2004368602 hasConceptScore W2004368602C2780062018 @default.
• W2004368602 hasConceptScore W2004368602C2781123555 @default.
• W2004368602 hasConceptScore W2004368602C2781161787 @default.
• W2004368602 hasConceptScore W2004368602C33789571 @default.
• W2004368602 hasConceptScore W2004368602C513476851 @default.
• W2004368602 hasConceptScore W2004368602C55493867 @default.
• W2004368602 hasConceptScore W2004368602C71924100 @default.
• W2004368602 hasConceptScore W2004368602C86803240 @default.
• W2004368602 hasIssue "3" @default.
• W2004368602 hasLocation W20043686021 @default.
• W2004368602 hasLocation W20043686022 @default.
• W2004368602 hasOpenAccess W2004368602 @default.
• W2004368602 hasPrimaryLocation W20043686021 @default.
• W2004368602 hasRelatedWork W1702318889 @default.
• W2004368602 hasRelatedWork W1978801406 @default.
• W2004368602 hasRelatedWork W1979999817 @default.

• next