FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004368685> ?p ?o ?g. }

• W2004368685 endingPage "607" @default.
• W2004368685 startingPage "601" @default.
• W2004368685 abstract "During kidney development, the metanephric mesenchyme (MM) develops into the nephron through mesenchymal-epithelial transition (MET). We have previously reported that knock-down of the expression of hepatocyte nuclear factor 4 alpha (Hnf4a) gene induces failure of cellular organization in the condensed mesenchyme (CM) of cultured embryonic kidneys. To elucidate the details of MET during nephrogenesis, embryonic mouse kidneys were analyzed by electron microscopy, immunohistochemistry, and molecular biology. The findings showed that the intercellular junction, but not the basal lamina, was present in the CM. Additionally, immediately after Hnf4a gene expression, the expression of epithelial genes (Krt8, Tjp1, and Cdh1) increased, and those of mesenchymal genes (Acta1 and Vim) decreased, in the CM compared to the MM. To clarify the relationship between MET and Hnf4α, the fibroblast cell line with forced expression of Hnf4α protein were analyzed. In this model, it was noted that Hnf4α induced increasing epithelial and decreasing mesenchymal gene expression. In these, up-regulation of Pvrl1, -2, and Mllt4 genes which mediate the formation of apico-basal polarity, were found. These results, and those of previous findings, indicate that Hnf4α protein is associated with the initiation of MET in early nephrogenesis." @default.
• W2004368685 created "2016-06-24" @default.
• W2004368685 creator A5008415687 @default.
• W2004368685 creator A5017042035 @default.
• W2004368685 creator A5036339962 @default.
• W2004368685 creator A5074622797 @default.
• W2004368685 creator A5081818104 @default.
• W2004368685 creator A5084209534 @default.
• W2004368685 date "2011-01-01" @default.
• W2004368685 modified "2023-10-15" @default.
• W2004368685 title "Hepatocyte Nuclear Factor 4 Alpha is Associated with Mesenchymal-Epithelial Transition in Developing Kidneys of C57BL/6 Mice" @default.
• W2004368685 cites W1972644970 @default.
• W2004368685 cites W1974939794 @default.
• W2004368685 cites W1980953487 @default.
• W2004368685 cites W1989418853 @default.
• W2004368685 cites W2003966651 @default.
• W2004368685 cites W2011599874 @default.
• W2004368685 cites W2018585471 @default.
• W2004368685 cites W2026158123 @default.
• W2004368685 cites W2033498252 @default.
• W2004368685 cites W2038747312 @default.
• W2004368685 cites W2039298921 @default.
• W2004368685 cites W2041575284 @default.
• W2004368685 cites W2045496667 @default.
• W2004368685 cites W2062835218 @default.
• W2004368685 cites W2062920754 @default.
• W2004368685 cites W2065321703 @default.
• W2004368685 cites W2067922543 @default.
• W2004368685 cites W2073641804 @default.
• W2004368685 cites W2077975622 @default.
• W2004368685 cites W2082078624 @default.
• W2004368685 cites W2082548402 @default.
• W2004368685 cites W2089693511 @default.
• W2004368685 cites W2091000930 @default.
• W2004368685 cites W2092207202 @default.
• W2004368685 cites W2118263188 @default.
• W2004368685 cites W2123679877 @default.
• W2004368685 cites W2139025111 @default.
• W2004368685 cites W2144398094 @default.
• W2004368685 cites W2150267721 @default.
• W2004368685 cites W2155013516 @default.
• W2004368685 cites W2164192503 @default.
• W2004368685 cites W2166694150 @default.
• W2004368685 cites W2891865053 @default.
• W2004368685 doi "https://doi.org/10.1292/jvms.10-0493" @default.
• W2004368685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21186337" @default.
• W2004368685 hasPublicationYear "2011" @default.
• W2004368685 type Work @default.
• W2004368685 sameAs 2004368685 @default.
• W2004368685 citedByCount "15" @default.
• W2004368685 countsByYear W20043686852012 @default.
• W2004368685 countsByYear W20043686852015 @default.
• W2004368685 countsByYear W20043686852016 @default.
• W2004368685 countsByYear W20043686852017 @default.
• W2004368685 countsByYear W20043686852018 @default.
• W2004368685 countsByYear W20043686852020 @default.
• W2004368685 countsByYear W20043686852021 @default.
• W2004368685 crossrefType "journal-article" @default.
• W2004368685 hasAuthorship W2004368685A5008415687 @default.
• W2004368685 hasAuthorship W2004368685A5017042035 @default.
• W2004368685 hasAuthorship W2004368685A5036339962 @default.
• W2004368685 hasAuthorship W2004368685A5074622797 @default.
• W2004368685 hasAuthorship W2004368685A5081818104 @default.
• W2004368685 hasAuthorship W2004368685A5084209534 @default.
• W2004368685 hasBestOaLocation W20043686851 @default.
• W2004368685 hasConcept C104317684 @default.
• W2004368685 hasConcept C105702510 @default.
• W2004368685 hasConcept C127561419 @default.
• W2004368685 hasConcept C145103041 @default.
• W2004368685 hasConcept C150194340 @default.
• W2004368685 hasConcept C153911025 @default.
• W2004368685 hasConcept C198826908 @default.
• W2004368685 hasConcept C2776340970 @default.
• W2004368685 hasConcept C2779333224 @default.
• W2004368685 hasConcept C54355233 @default.
• W2004368685 hasConcept C76419328 @default.
• W2004368685 hasConcept C86803240 @default.
• W2004368685 hasConcept C87555872 @default.
• W2004368685 hasConcept C95444343 @default.
• W2004368685 hasConcept C99535661 @default.
• W2004368685 hasConceptScore W2004368685C104317684 @default.
• W2004368685 hasConceptScore W2004368685C105702510 @default.
• W2004368685 hasConceptScore W2004368685C127561419 @default.
• W2004368685 hasConceptScore W2004368685C145103041 @default.
• W2004368685 hasConceptScore W2004368685C150194340 @default.
• W2004368685 hasConceptScore W2004368685C153911025 @default.
• W2004368685 hasConceptScore W2004368685C198826908 @default.
• W2004368685 hasConceptScore W2004368685C2776340970 @default.
• W2004368685 hasConceptScore W2004368685C2779333224 @default.
• W2004368685 hasConceptScore W2004368685C54355233 @default.
• W2004368685 hasConceptScore W2004368685C76419328 @default.
• W2004368685 hasConceptScore W2004368685C86803240 @default.
• W2004368685 hasConceptScore W2004368685C87555872 @default.
• W2004368685 hasConceptScore W2004368685C95444343 @default.
• W2004368685 hasConceptScore W2004368685C99535661 @default.
• W2004368685 hasIssue "5" @default.
• W2004368685 hasLocation W20043686851 @default.
• W2004368685 hasLocation W20043686852 @default.

• next