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- W2004369526 abstract "Nanoparticles of polyisohexylcyanoacrylate with bound primaquine were prepared by an emulsion polymerization method and an i.v. formulation was obtained after freeze-drying. Such formulation is intended for drug targeting in visceral leishmaniasis. Drug binding seemed largely dependent on pH and formulation conditions were optimized to obtain a polymeric colloidal suspension containing particles in the 200-250 nm size range and 80-90% drug binding (final content of 10 mg of drug per vial). Aspects such as polymer-drug interaction, in vitro drug release and physicochemical stability were studied. A significant reduction in acute toxicity was demonstrated by using the targeted formulation in NMRI mice." @default.
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- W2004369526 date "1991-02-01" @default.
- W2004369526 modified "2023-10-18" @default.
- W2004369526 title "Nanoparticles of polyisohexylcyanoaerylate (PIHCA) as carriers of primaquine: formulation, physico-chemical characterization and acute toxicity" @default.
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- W2004369526 doi "https://doi.org/10.1016/0378-5173(91)90133-9" @default.
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