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- W2004374311 abstract "The effective treatment of malaria can be very complex: Plasmodium parasites develop in multiple stages within a complex life cycle between mosquitoes as vectors and vertebrates as hosts. For the full and effective elimination of parasites, an effective drug should be active against the earliest stages of the Plasmodium infection: liver stages (reduce the progress of the infection), blood stages (cure the clinical symptoms), and gametocytes (inhibit the transmission cycle). Towards this goal, here we report the design, the synthetic methodology, and the characterization of novel hybrid agents with combined activity against Plasmodium liver stages and blood stages and gametocytes. The divergent synthetic approach allows the access to differently linked primaquine-chloroquine hybrid templates in up to eight steps." @default.
- W2004374311 created "2016-06-24" @default.
- W2004374311 creator A5077643124 @default.
- W2004374311 creator A5082544857 @default.
- W2004374311 date "2015-02-05" @default.
- W2004374311 modified "2023-10-18" @default.
- W2004374311 title "Design and Synthesis of Novel Hybrid Molecules against Malaria" @default.
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- W2004374311 doi "https://doi.org/10.1155/2015/458319" @default.
- W2004374311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4334980" @default.
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