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- W2004378836 abstract "Previous studies have shown that cellular prion protein (PrPC) plays anti-apoptotic and anti-oxidative role against cell death induced by serum-deprivation (SDP) in an immortalized prion protein gene-deficient neuronal cell line derived from Rikn prion protein (PrP) gene-deficient (Prnp–/–) mice, which ectopically produce excess Doppel (Dpl) (PrP-like glycoprotein). To investigate whether PrPC inhibits apoptotic neuronal cell death without Dpl, an immortalized cell line was established from the brain of ZrchI Prnp–/– mice, which do not show ectopic expression of Dpl. The results using a ZrchI neuronal Prnp–/– cell line (NpL2) showed that PrPC potently inhibited SDP-induced apoptotic cell death. Furthermore, PrPC expression enhanced the superoxide dismutase (SOD) activity in NpL2 cells. These results indicate that Dpl production did not affect anti-apoptotic and anti-oxidative functions of PrP, suggesting that PrPC may be directly correlated with protection against oxidative stress." @default.
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- W2004378836 date "2007-04-01" @default.
- W2004378836 modified "2023-10-02" @default.
- W2004378836 title "Serum Withdrawal-Induced Apoptosis in ZrchI Prion Protein (PrP) Gene-Deficient Neuronal Cell Line Is Suppressed by PrP, Independent of Doppel" @default.
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- W2004378836 doi "https://doi.org/10.1111/j.1348-0421.2007.tb03920.x" @default.
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