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- W2004379652 abstract "3-Methylindole (3MI) is a ruminal fermentation product of cryptophan that causes acute lung injury in ruminants, horses, and some other animals. Injury to the lung is cellular and species specific. Cytotoxic effects art mediated through mixed function oxidase metabolism of 3MI which causes the formantion of a reactive intermediate that covalently binds to cellular macromolecules. The reactive intermediate can be detoxified by conjugation with glutathione (GSH) to form a 3MI-GSH adduct. This adduct was isolated using HPLC and the structure was determined using W spectrometry, thermospray liquid chromotography/mass spectrometry, and nuclear agnetic resonance spectrometry. The structure of the 3MI-GSH-adduct was shown to be 3-(glutathion-S-yl)-methyi Indole. The most likely structure of the reactive intermediate responsible for acute lung injury is the imine methide of 3MI." @default.
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- W2004379652 date "1986-01-01" @default.
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- W2004379652 title "Recent Findings on the Chemical Nature and Biochemical Mechanisms of the Toxic Agent Involved in 3-Methylindole-Induced Acute Lung Injury" @default.
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- W2004379652 doi "https://doi.org/10.3109/15569548609012717" @default.
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