Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004382195> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2004382195 abstract "Objective: To report 2 patients who presented with retinal hemorrhages while being treated with a continuous regimen of anti-tuberculous drugs. Case Summaries: Two women, one suffering from tuberculous infection of the lungs and the other from disseminated Koch's, were treated with a daily regimen of anti-tuberculous therapy consisting of rifampin, isoniazid, pyrazinamide, and ethambutol. On initiation of treatment, these patients did not have any systemic or ocular disease, and hematologic investigations, kidney function tests, and liver function tests were normal. Within 2 weeks of initiation of anti-tuberculous therapy, both women had transient renal function deterioration. Additionally, each had a single episode of retinal hemorrhage. While the patients remained under treatment with the same drugs, both of these adverse effects resolved spontaneously within a short period. According to the Naranjo probability scale, this reaction was probable. Discussion: The renal dysfunction and retinal hemorrhages in both of our patients were most probably due to anti-tuberculous drug-induced antibodies. A continuous mode of anti-tuberculous drug administration causes immunologic tolerance due to simultaneous neutralization of drug-induced antibodies. As the antibodies were short-lived, renal impairment, thrombocytopenia, and retinal hemorrhages in both of our patients were transient. Conclusions: The continuous regimen of anti-tuberculous drug administration is safer than intermittent therapy. In patients receiving treatment with these drugs, hepatic, hematologic, renal, and ocular parameters should be regularly monitored." @default.
- W2004382195 created "2016-06-24" @default.
- W2004382195 creator A5008076823 @default.
- W2004382195 creator A5036680659 @default.
- W2004382195 creator A5070373978 @default.
- W2004382195 creator A5076700085 @default.
- W2004382195 date "2004-09-01" @default.
- W2004382195 modified "2023-09-26" @default.
- W2004382195 title "Appearance of Retinal Hemorrhages in Patients on Daily-Dose Anti-Tubercular Therapy" @default.
- W2004382195 cites W1963975384 @default.
- W2004382195 cites W1978629068 @default.
- W2004382195 cites W1987894092 @default.
- W2004382195 cites W1988165262 @default.
- W2004382195 cites W2008756350 @default.
- W2004382195 cites W2018473673 @default.
- W2004382195 cites W2027148941 @default.
- W2004382195 cites W2046871520 @default.
- W2004382195 cites W2050265650 @default.
- W2004382195 cites W2067978628 @default.
- W2004382195 cites W2089143030 @default.
- W2004382195 cites W2150690887 @default.
- W2004382195 cites W2155146282 @default.
- W2004382195 cites W2336841031 @default.
- W2004382195 cites W1989275318 @default.
- W2004382195 doi "https://doi.org/10.1177/875512250402000504" @default.
- W2004382195 hasPublicationYear "2004" @default.
- W2004382195 type Work @default.
- W2004382195 sameAs 2004382195 @default.
- W2004382195 citedByCount "0" @default.
- W2004382195 crossrefType "journal-article" @default.
- W2004382195 hasAuthorship W2004382195A5008076823 @default.
- W2004382195 hasAuthorship W2004382195A5036680659 @default.
- W2004382195 hasAuthorship W2004382195A5070373978 @default.
- W2004382195 hasAuthorship W2004382195A5076700085 @default.
- W2004382195 hasConcept C126322002 @default.
- W2004382195 hasConcept C141071460 @default.
- W2004382195 hasConcept C142724271 @default.
- W2004382195 hasConcept C159641895 @default.
- W2004382195 hasConcept C197934379 @default.
- W2004382195 hasConcept C2776228421 @default.
- W2004382195 hasConcept C2776967927 @default.
- W2004382195 hasConcept C2778062832 @default.
- W2004382195 hasConcept C2780035454 @default.
- W2004382195 hasConcept C2780459521 @default.
- W2004382195 hasConcept C2781069245 @default.
- W2004382195 hasConcept C2781413609 @default.
- W2004382195 hasConcept C500440147 @default.
- W2004382195 hasConcept C71924100 @default.
- W2004382195 hasConcept C90924648 @default.
- W2004382195 hasConcept C98274493 @default.
- W2004382195 hasConceptScore W2004382195C126322002 @default.
- W2004382195 hasConceptScore W2004382195C141071460 @default.
- W2004382195 hasConceptScore W2004382195C142724271 @default.
- W2004382195 hasConceptScore W2004382195C159641895 @default.
- W2004382195 hasConceptScore W2004382195C197934379 @default.
- W2004382195 hasConceptScore W2004382195C2776228421 @default.
- W2004382195 hasConceptScore W2004382195C2776967927 @default.
- W2004382195 hasConceptScore W2004382195C2778062832 @default.
- W2004382195 hasConceptScore W2004382195C2780035454 @default.
- W2004382195 hasConceptScore W2004382195C2780459521 @default.
- W2004382195 hasConceptScore W2004382195C2781069245 @default.
- W2004382195 hasConceptScore W2004382195C2781413609 @default.
- W2004382195 hasConceptScore W2004382195C500440147 @default.
- W2004382195 hasConceptScore W2004382195C71924100 @default.
- W2004382195 hasConceptScore W2004382195C90924648 @default.
- W2004382195 hasConceptScore W2004382195C98274493 @default.
- W2004382195 hasLocation W20043821951 @default.
- W2004382195 hasOpenAccess W2004382195 @default.
- W2004382195 hasPrimaryLocation W20043821951 @default.
- W2004382195 hasRelatedWork W1963975384 @default.
- W2004382195 hasRelatedWork W2014549521 @default.
- W2004382195 hasRelatedWork W2059457645 @default.
- W2004382195 hasRelatedWork W2186457922 @default.
- W2004382195 hasRelatedWork W2212186768 @default.
- W2004382195 hasRelatedWork W2410002868 @default.
- W2004382195 hasRelatedWork W4221063016 @default.
- W2004382195 hasRelatedWork W4236653558 @default.
- W2004382195 hasRelatedWork W94106818 @default.
- W2004382195 hasRelatedWork W2305409500 @default.
- W2004382195 isParatext "false" @default.
- W2004382195 isRetracted "false" @default.
- W2004382195 magId "2004382195" @default.
- W2004382195 workType "article" @default.