Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004386069> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2004386069 endingPage "63" @default.
- W2004386069 startingPage "61" @default.
- W2004386069 abstract "A new therapy is enormously expensive: it costs up to $350 million to bring a new drug to market, or more than $500 million if failures are taken into account, most of the money going to meet the regulatory requirements for phase II and phase III clinical trials. Generally, only big companies can afford such investments and provide the organisation needed for clinical drug development, a process that in the 1980s took on average 13–15 years from chemical synthesis to marketing approval. 1 DiMasi JA Seibring MA Lasagna L New drug development in the United States from 1963 to 1992. Clin Pharmacol Ther. 1994; 55: 609-622 Crossref PubMed Scopus (63) Google Scholar Evolutionary pressure is immense, and the clinical success rate of new drugs registered with the US Food and Drug Administration (FDA) and tested in man is about one in five. 2 Bienz-Tadmor B Dicerbo PA Tadmar G Lasagna L Biopharmaceuticals and conventional drugs: clinical success rates. Biotechnology. 1992; 10: 521-525 Crossref PubMed Scopus (32) Google Scholar" @default.
- W2004386069 created "2016-06-24" @default.
- W2004386069 creator A5020477659 @default.
- W2004386069 creator A5029677573 @default.
- W2004386069 date "2000-01-01" @default.
- W2004386069 modified "2023-09-27" @default.
- W2004386069 title "A drug on the market?" @default.
- W2004386069 cites W1972371265 @default.
- W2004386069 cites W1975696039 @default.
- W2004386069 cites W1981631743 @default.
- W2004386069 cites W1984201547 @default.
- W2004386069 cites W1986999643 @default.
- W2004386069 cites W1987179124 @default.
- W2004386069 cites W1991576961 @default.
- W2004386069 cites W2009937460 @default.
- W2004386069 cites W2032165999 @default.
- W2004386069 cites W2034109892 @default.
- W2004386069 cites W2044806682 @default.
- W2004386069 cites W2045549484 @default.
- W2004386069 cites W2049858570 @default.
- W2004386069 cites W2051865088 @default.
- W2004386069 cites W2053095574 @default.
- W2004386069 cites W2067820229 @default.
- W2004386069 cites W2070114315 @default.
- W2004386069 cites W2085777030 @default.
- W2004386069 cites W2124687416 @default.
- W2004386069 cites W2126926695 @default.
- W2004386069 cites W2138168864 @default.
- W2004386069 cites W2151702699 @default.
- W2004386069 cites W2419609760 @default.
- W2004386069 cites W2917729748 @default.
- W2004386069 doi "https://doi.org/10.1016/s0140-6736(99)07304-3" @default.
- W2004386069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10615905" @default.
- W2004386069 hasPublicationYear "2000" @default.
- W2004386069 type Work @default.
- W2004386069 sameAs 2004386069 @default.
- W2004386069 citedByCount "11" @default.
- W2004386069 countsByYear W20043860692018 @default.
- W2004386069 crossrefType "journal-article" @default.
- W2004386069 hasAuthorship W2004386069A5020477659 @default.
- W2004386069 hasAuthorship W2004386069A5029677573 @default.
- W2004386069 hasConcept C126322002 @default.
- W2004386069 hasConcept C144133560 @default.
- W2004386069 hasConcept C17744445 @default.
- W2004386069 hasConcept C199539241 @default.
- W2004386069 hasConcept C2779473830 @default.
- W2004386069 hasConcept C2780035454 @default.
- W2004386069 hasConcept C3018890749 @default.
- W2004386069 hasConcept C535046627 @default.
- W2004386069 hasConcept C64903051 @default.
- W2004386069 hasConcept C71924100 @default.
- W2004386069 hasConcept C83867959 @default.
- W2004386069 hasConcept C98274493 @default.
- W2004386069 hasConceptScore W2004386069C126322002 @default.
- W2004386069 hasConceptScore W2004386069C144133560 @default.
- W2004386069 hasConceptScore W2004386069C17744445 @default.
- W2004386069 hasConceptScore W2004386069C199539241 @default.
- W2004386069 hasConceptScore W2004386069C2779473830 @default.
- W2004386069 hasConceptScore W2004386069C2780035454 @default.
- W2004386069 hasConceptScore W2004386069C3018890749 @default.
- W2004386069 hasConceptScore W2004386069C535046627 @default.
- W2004386069 hasConceptScore W2004386069C64903051 @default.
- W2004386069 hasConceptScore W2004386069C71924100 @default.
- W2004386069 hasConceptScore W2004386069C83867959 @default.
- W2004386069 hasConceptScore W2004386069C98274493 @default.
- W2004386069 hasIssue "9197" @default.
- W2004386069 hasLocation W20043860691 @default.
- W2004386069 hasLocation W20043860692 @default.
- W2004386069 hasOpenAccess W2004386069 @default.
- W2004386069 hasPrimaryLocation W20043860691 @default.
- W2004386069 hasRelatedWork W2009053354 @default.
- W2004386069 hasRelatedWork W2025686510 @default.
- W2004386069 hasRelatedWork W2329258414 @default.
- W2004386069 hasRelatedWork W2372770165 @default.
- W2004386069 hasRelatedWork W2387362168 @default.
- W2004386069 hasRelatedWork W2388075619 @default.
- W2004386069 hasRelatedWork W2528167051 @default.
- W2004386069 hasRelatedWork W2954883126 @default.
- W2004386069 hasRelatedWork W4301195367 @default.
- W2004386069 hasRelatedWork W4301249780 @default.
- W2004386069 hasVolume "355" @default.
- W2004386069 isParatext "false" @default.
- W2004386069 isRetracted "false" @default.
- W2004386069 magId "2004386069" @default.
- W2004386069 workType "article" @default.