FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004386819> ?p ?o ?g. }

• W2004386819 endingPage "404" @default.
• W2004386819 startingPage "395" @default.
• W2004386819 abstract "Injury to the renal proximal tubule is common and may be followed by either recovery or cell death. The survival of injured cells is supported by a transient change in cellular metabolism that maintains life even when oxygen tension is reduced. This adaptive process involves the activation of the gene encoding the glucose transporter GLUT1, which is essential to maintain the high rates of glucose influx demanded by glycolysis. We hypothesized that after cell injury increases of cell Ca2+ (Ca2+i) initiate the flow of information that culminates with the upregulation of the stress response gene GLUT1. We found that elevations of Ca2+i caused by the calcium ionophore A23187 activated the expression of the GLUT1 gene in LLC-PK1 cells. The stimulatory effect of Ca2+i on GLUT1 gene expression was, at least in part, transcriptional and resulted in higher levels of GLUT1 mRNA, cognate protein, cellular hexose transport activity, glucose consumption, and lactate production. This response was vital to the renal cells, as its interruption severely increased Ca2+-induced cytotoxicity and cell mortality. We propose that increases of Ca2+i initiate stress responses, represented in part by activation of the GLUT1 gene, and that disruption to the flow of information originating from Ca2+-induced stress, or to the coordinated expression of the stress response, prevents cell recovery after injury and may be an important cause of permanent renal cell injury and cell death." @default.
• W2004386819 created "2016-06-24" @default.
• W2004386819 creator A5014844620 @default.
• W2004386819 creator A5021352433 @default.
• W2004386819 creator A5027676805 @default.
• W2004386819 creator A5032229342 @default.
• W2004386819 creator A5040885448 @default.
• W2004386819 creator A5077975973 @default.
• W2004386819 creator A5089551299 @default.
• W2004386819 date "1996-07-15" @default.
• W2004386819 modified "2023-09-26" @default.
• W2004386819 title "Studies of renal injury. II. Activation of the glucose transporter 1 (GLUT1) gene and glycolysis in LLC-PK1 cells under Ca2+ stress." @default.
• W2004386819 cites W130249857 @default.
• W2004386819 cites W1483367645 @default.
• W2004386819 cites W1489669524 @default.
• W2004386819 cites W1494951884 @default.
• W2004386819 cites W1504260229 @default.
• W2004386819 cites W1505781390 @default.
• W2004386819 cites W1522864419 @default.
• W2004386819 cites W1529962599 @default.
• W2004386819 cites W1537045952 @default.
• W2004386819 cites W1539324930 @default.
• W2004386819 cites W1569469862 @default.
• W2004386819 cites W1593417211 @default.
• W2004386819 cites W1876309946 @default.
• W2004386819 cites W1977779461 @default.
• W2004386819 cites W1998833148 @default.
• W2004386819 cites W2010356985 @default.
• W2004386819 cites W2014669590 @default.
• W2004386819 cites W2016874853 @default.
• W2004386819 cites W2018289835 @default.
• W2004386819 cites W2026129689 @default.
• W2004386819 cites W2033806266 @default.
• W2004386819 cites W2042188303 @default.
• W2004386819 cites W2049341586 @default.
• W2004386819 cites W2063450941 @default.
• W2004386819 cites W2071063451 @default.
• W2004386819 cites W2073347694 @default.
• W2004386819 cites W2077077811 @default.
• W2004386819 cites W2090868158 @default.
• W2004386819 cites W2092468599 @default.
• W2004386819 cites W2096996169 @default.
• W2004386819 cites W2100837269 @default.
• W2004386819 cites W2101108802 @default.
• W2004386819 cites W2102537613 @default.
• W2004386819 cites W2115169777 @default.
• W2004386819 cites W2128635872 @default.
• W2004386819 cites W2134812217 @default.
• W2004386819 cites W2136520136 @default.
• W2004386819 cites W2144206181 @default.
• W2004386819 cites W2157838103 @default.
• W2004386819 cites W2158122411 @default.
• W2004386819 cites W2175640662 @default.
• W2004386819 cites W2181020360 @default.
• W2004386819 cites W2265051930 @default.
• W2004386819 cites W2272927049 @default.
• W2004386819 cites W2281844621 @default.
• W2004386819 cites W2308819146 @default.
• W2004386819 cites W2312173669 @default.
• W2004386819 cites W2341586023 @default.
• W2004386819 cites W2380936111 @default.
• W2004386819 cites W2409659368 @default.
• W2004386819 cites W2417432219 @default.
• W2004386819 cites W2417763973 @default.
• W2004386819 cites W2466290494 @default.
• W2004386819 doi "https://doi.org/10.1172/jci118805" @default.
• W2004386819 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507443" @default.
• W2004386819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8755650" @default.
• W2004386819 hasPublicationYear "1996" @default.
• W2004386819 type Work @default.
• W2004386819 sameAs 2004386819 @default.
• W2004386819 citedByCount "20" @default.
• W2004386819 countsByYear W20043868192019 @default.
• W2004386819 countsByYear W20043868192022 @default.
• W2004386819 crossrefType "journal-article" @default.
• W2004386819 hasAuthorship W2004386819A5014844620 @default.
• W2004386819 hasAuthorship W2004386819A5021352433 @default.
• W2004386819 hasAuthorship W2004386819A5027676805 @default.
• W2004386819 hasAuthorship W2004386819A5032229342 @default.
• W2004386819 hasAuthorship W2004386819A5040885448 @default.
• W2004386819 hasAuthorship W2004386819A5077975973 @default.
• W2004386819 hasAuthorship W2004386819A5089551299 @default.
• W2004386819 hasBestOaLocation W20043868191 @default.
• W2004386819 hasConcept C104317684 @default.
• W2004386819 hasConcept C127561419 @default.
• W2004386819 hasConcept C134018914 @default.
• W2004386819 hasConcept C150194340 @default.
• W2004386819 hasConcept C161573976 @default.
• W2004386819 hasConcept C185592680 @default.
• W2004386819 hasConcept C190283241 @default.
• W2004386819 hasConcept C20251656 @default.
• W2004386819 hasConcept C2777866211 @default.
• W2004386819 hasConcept C2777952866 @default.
• W2004386819 hasConcept C2779306644 @default.
• W2004386819 hasConcept C2908666080 @default.
• W2004386819 hasConcept C31573885 @default.
• W2004386819 hasConcept C55493867 @default.
• W2004386819 hasConcept C62231903 @default.

• next