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• W2004387061 startingPage "893" @default.
• W2004387061 abstract "Three “blood substitutes,” a diaspirin cross-linked human hemoglobin (DBBF-Hb), a bovine polymerized hemoglobin (PolyHbBv), and a human polymerized hemoglobin ( O-R-PolyHbA 0 ), that have undergone clinical trials are used in this study. Previously, we showed in the rat that coadministration of sodium selenite (Na 2 SeO 3 ) and DBBF-Hb significantly decreased mesenteric venular leakage and epithelial disruption produced by DBBF-Hb alone but did not reduce mast cell degranulation unless given orally. The purpose of this study was to determine whether Na 2 SeO 3 produced similar beneficial responses when used with PolyHbBv and O-R-PolyHbA 0 . In anesthetized Sprague-Dawley rats, the mesenteric microvasculature was perfused with PolyHbBv or O-R-PolyHbA 0 , with and without Na 2 SeO 3 in the perfusate and suffusate, for 10 min, followed by FITC-albumin for 3 min, and then fixed for microscopy. Na 2 SeO 3 did not reduce leak number or area in preparations perfused with PolyHbBv and only reduced leak number (but not significantly) in preparations perfused with O-R-PolyHbA 0 . Na 2 SeO 3 significantly increased mesenteric mast cell degranulation and impaired epithelial integrity in animals treated with PolyHbBv. In vitro, Na 2 SeO 3 significantly reduced the oxidation rate of DBBF-Hb in the presence of oxidants, had little effect on PolyHbBv, and increased the oxidation rate of O-R-PolyHbA 0 . These results suggest that Na 2 SeO 3 moderates hemoglobin-induced damage, at least partly, through its redox interactions with the heme sites in the hemoglobin molecules studied and that accessibility of the heme site to Na 2 SeO 3 governs those interactions." @default.
• W2004387061 created "2016-06-24" @default.
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• W2004387061 date "2004-03-01" @default.
• W2004387061 modified "2023-10-08" @default.
• W2004387061 title "Differential effects of sodium selenite in reducing tissue damage caused by three hemoglobin-based oxygen carriers" @default.
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• W2004387061 doi "https://doi.org/10.1152/japplphysiol.00615.2003" @default.
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