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• W2004389367 abstract "Abstract Calcitriol acts via its receptor (VDR) and inhibits PTH secretion and parathyroid cell proliferation. Increased prevalence of the polymorphic VDR alleles b, a, and T has been demonstrated in sporadic primary hyperparathyroidism. Sixty-two patients with primary hyperparathyroidism due to parathyroid adenoma (mean age, 69.5 ± 1.4 yr) were genotyped for these VDR polymorphisms. Dispersed cells of the adenomas were exposed to increasing concentrations of extracellular Ca2+ and analyzed for PTH release and cytoplasmic Ca2+ concentrations. Ca2+-mediated PTH inhibition exhibited higher ED50 and less suppression in the cells of patients who were homozygous for the b, a, and T alleles (P &lt; 0.05–0.10). When analyzing haplotypes, the patients with baT demonstrated a ED50 of 1.81 ± 0.15 vs. 1.29 ± 0.10 for BAt (P &lt; 0.05). As VDR alleles were unrelated to parathyroid intracellular Ca2+, influences of polymorphic VDR alleles on PTH secretion seem to involve mechanisms other than the Ca2+-sensing protein of the parathyroid cell surface." @default.
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• W2004389367 date "1997-06-01" @default.
• W2004389367 modified "2023-10-12" @default.
• W2004389367 title "Vitamin D Receptor Polymorphisms Correlate to Parathyroid Cell Function in Primary Hyperparathyroidism1" @default.
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• W2004389367 doi "https://doi.org/10.1210/jcem.82.6.4012" @default.
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