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- W2004390021 abstract "Thioacetamide and one of its metabolite, thioacetamide-S-oxide, were shown to increase heme oxygenase and to inhibit δ-aminolevulinic acid (ALA) synthetase when administered in vivo to male rats. Concomitant with the increase of heme oxygenase and the decrease of ALA synthetase, concentration of cytochrome P-450 and drug metabolizing enzyme activities were decreased by in vivo administration of thioacetamide and thioacetamide-S-oxide to rats. The results of these studies indicate that thioacetamide and thioacetamide-S-oxide are not only inhibitor of ALA synthetase, but also inducer of heme oxygenase in rats. Further, thioacetamide-S-oxide is generally more effective than thioacetamide with respect to the effects on cytochrome P-450, ALA synthetase and heme oxygenase" @default.
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- W2004390021 date "1983-01-01" @default.
- W2004390021 modified "2023-10-09" @default.
- W2004390021 title "Induction of heme oxygenase and inhibition of .DELTA.-aminolevulinic acid synthetase of rat liver by thioacetamide and thioacetamide-S-oxide." @default.
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- W2004390021 doi "https://doi.org/10.1248/bpb1978.6.340" @default.
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