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- W2004390917 abstract "The effects of indapamide on contractile responses in various isolated artery rings and on spontaneous mechanical activity in portal vein segments were investigated. Arteries used were: rabbit aorta, mesenteric (fifth branch), femoral and basilar, and sheep coronary arteries. 45Ca2+ uptake was also analysed in rabbit mesenteric arteries. Indapamide (10−10−3 × 10−4 M) produced a concentration-dependent inhibition of the contractile responses induced by high K+ (80 mM), 5-hydroxytryptamine (10−5 M), and noradrenaline (10−6 or 10−4 M) in all the arteries studied. The inhibitory effect was greater in mesenteric (fifth branch) the IC50 values being 9.2±3.0 × 10−6 and 5.5±4.0 × 10−8 M for depression of high K+- and agonist-induced contractions, respectively. Indapamide inhibited in a concentration-dependent manner the contractile responses elicited by the addition of Ca2+ (1–5 mM) to Ca2+-free high K+ solution as well as the spontaneous mechanical activity of rat portal vein. Indapamide also reduced the 45Ca2+ uptake in rabbit mesenteric arteries stimulated by noradrenaline (10−4 M) or high K+ (80 mM) without affecting the Ca2+ influx in resting tissues. Our results indicate that indapamide blocked both depolarization- demonstrated to be the arteries most sensitive to indapamide vascular effects." @default.
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- W2004390917 title "Effects of indapamide on contractile responses and 45Ca2+ movements in various isolated blood vessels" @default.
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- W2004390917 doi "https://doi.org/10.1016/0014-2999(93)90630-z" @default.
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