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- W2004391423 abstract "WE recently showed that s.c. injections of a nonimmunosuppressant FK506 binding protein-12 (FKBP-12) ligand (V-10,367) accelerates nerve regeneration in the rat sciatic nerve crush model. Here we examined the oral efficacy of this compound for speeding nerve regeneration. Rats receiving V-10,367 (5, 15 or 50 mg/kg/day) by oral gavage all demonstrated an increase in nerve regeneration compared to vehicle-treated controls. Functional recovery was observed earliest and axonal calibers of regenerating axons in the soleus nerve were largest in the 15 mg/kg group, mean axonal areas being increased by 66% compared to controls. Orally active nonimmunosuppressant FKBP-12 ligands may be useful for the treatment of human peripheral nerve disorders." @default.
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- W2004391423 date "1998-02-01" @default.
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- W2004391423 title "Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration" @default.
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- W2004391423 doi "https://doi.org/10.1097/00001756-199802160-00031" @default.
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