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• W2004391477 abstract "Oviducts and uteri were obtained from cats at estrus and up to 14 days after coitus. Progesterone binding sites were estimated by Scatchard analysis, serum levels of progesterone were determined by radioimmunoassay, and key morphological parameters of the lining of the epithelium of the oviduct and the deep uterine glands were quantitated. Progesterone cytosol binding was hightest at estrus, significantly depleted by day 4, and continued a gradual decline out to day 14 in both tissues. Nuclear binding was markedly elevated at day 4; with time the binding decreased until by day 14 it was equal to or lower than detected at estrus. The initial depletion of cytosol binding and rise in nuclear binding coincided with the initial rise in serum progesterone levels. Within the oviduct, the increase in nuclear binding coincided with the onsdet of regressive changes within the epithelium. These changes included atrophy, deciliation, and apotosis. Within the uterine glands, the increase in nuclear binding coincided with the onset of the progestational response. This response included cell hypertrophy, glycogen synthesis and deposition, and with longer exposure to elevated levels of progesterone, the disappearance of these glycogen deposits. These results clearly illustrate the immediate effect of low levels of progesterone on the subcellular compartmentalization of the progesterone receptor system, and the down regulation of the total receptor system when target tissues are exposed to a continuous elevation of serum progesterone. These result also illustrate that similar changes in receptor compartmentalization induce different morphological responses within target tissues from the same animal." @default.
• W2004391477 created "2016-06-24" @default.
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• W2004391477 date "1984-04-01" @default.
• W2004391477 modified "2023-09-27" @default.
• W2004391477 title "The postovulatory cat oviduct and uterus: Correlation of morphological features with progesterone receptor levels" @default.
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• W2004391477 doi "https://doi.org/10.1002/ar.1092080408" @default.
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