Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004394004> ?p ?o ?g. }
- W2004394004 endingPage "115" @default.
- W2004394004 startingPage "107" @default.
- W2004394004 abstract "Squamous cell carcinoma of the oesophagus (SCCO) is still a pathology of bad prognosis. Specific therapies are now developed against epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2, c-kit receptor (CD117), vascular endothelial growth factor (VEGF) and p53 protein. This study was aimed at assessing their expression in a large series of SCCO, as well as their potential therapeutic interest in this pathology. Immunohistochemical expression of these factors was assessed retrospectively in 107 cases of SCCO with primary surgery, as well as their relationships to recurrence, metastasis and overall survival on a long-term follow-up. Human epidermal growth factor receptor 2 and CD117 were expressed in less than 3% of the cases. Epidermal growth factor receptor and p53 were overexpressed in 68.2 and 66.4% of the cases, and VEGF in 38.3%. Epidermal growth factor receptor overexpression was significantly related to vascular invasion (P=0.023). Its diffuse positivity was significantly related in multivariate analysis to higher local recurrence (P=0.006) and lower overall survival (P=0.003), in a subgroup of patients of poor outcome who had received postoperative adjuvant treatment. These results highlight the great potential prognostic and therapeutic interest of evaluating EGFR diffuse positivity in locally advanced SCCO." @default.
- W2004394004 created "2016-06-24" @default.
- W2004394004 creator A5011538792 @default.
- W2004394004 creator A5027056624 @default.
- W2004394004 creator A5036980881 @default.
- W2004394004 creator A5047204004 @default.
- W2004394004 creator A5064264902 @default.
- W2004394004 creator A5066673105 @default.
- W2004394004 creator A5067653900 @default.
- W2004394004 creator A5069777709 @default.
- W2004394004 date "2005-06-28" @default.
- W2004394004 modified "2023-10-18" @default.
- W2004394004 title "Diffuse EGFR staining is associated with reduced overall survival in locally advanced oesophageal squamous cell cancer" @default.
- W2004394004 cites W1550092936 @default.
- W2004394004 cites W1599960633 @default.
- W2004394004 cites W1752312133 @default.
- W2004394004 cites W1891593892 @default.
- W2004394004 cites W1920900131 @default.
- W2004394004 cites W1976431241 @default.
- W2004394004 cites W1983439940 @default.
- W2004394004 cites W1989180603 @default.
- W2004394004 cites W1996552994 @default.
- W2004394004 cites W2001751294 @default.
- W2004394004 cites W2004898879 @default.
- W2004394004 cites W2006590541 @default.
- W2004394004 cites W2016568386 @default.
- W2004394004 cites W2023575200 @default.
- W2004394004 cites W2030725776 @default.
- W2004394004 cites W2032359283 @default.
- W2004394004 cites W2032955821 @default.
- W2004394004 cites W2038596108 @default.
- W2004394004 cites W2055280366 @default.
- W2004394004 cites W2057458801 @default.
- W2004394004 cites W2061119693 @default.
- W2004394004 cites W2063436204 @default.
- W2004394004 cites W2065564885 @default.
- W2004394004 cites W2067484068 @default.
- W2004394004 cites W2067754613 @default.
- W2004394004 cites W2072402041 @default.
- W2004394004 cites W2092732346 @default.
- W2004394004 cites W2092960407 @default.
- W2004394004 cites W2097382995 @default.
- W2004394004 cites W2108145145 @default.
- W2004394004 cites W2117089661 @default.
- W2004394004 cites W2121831273 @default.
- W2004394004 cites W2123206362 @default.
- W2004394004 cites W2154200023 @default.
- W2004394004 cites W2157367164 @default.
- W2004394004 cites W2157769714 @default.
- W2004394004 cites W2159363679 @default.
- W2004394004 cites W2168377135 @default.
- W2004394004 cites W2276191393 @default.
- W2004394004 cites W2318605753 @default.
- W2004394004 cites W2408176556 @default.
- W2004394004 cites W2411605089 @default.
- W2004394004 cites W2429605892 @default.
- W2004394004 cites W2469301322 @default.
- W2004394004 cites W2498353311 @default.
- W2004394004 cites W4235333461 @default.
- W2004394004 cites W4241370600 @default.
- W2004394004 cites W4247164694 @default.
- W2004394004 doi "https://doi.org/10.1038/sj.bjc.6602625" @default.
- W2004394004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2361490" @default.
- W2004394004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15986037" @default.
- W2004394004 hasPublicationYear "2005" @default.
- W2004394004 type Work @default.
- W2004394004 sameAs 2004394004 @default.
- W2004394004 citedByCount "133" @default.
- W2004394004 countsByYear W20043940042012 @default.
- W2004394004 countsByYear W20043940042013 @default.
- W2004394004 countsByYear W20043940042014 @default.
- W2004394004 countsByYear W20043940042015 @default.
- W2004394004 countsByYear W20043940042016 @default.
- W2004394004 countsByYear W20043940042017 @default.
- W2004394004 countsByYear W20043940042018 @default.
- W2004394004 countsByYear W20043940042019 @default.
- W2004394004 countsByYear W20043940042020 @default.
- W2004394004 countsByYear W20043940042021 @default.
- W2004394004 countsByYear W20043940042022 @default.
- W2004394004 countsByYear W20043940042023 @default.
- W2004394004 crossrefType "journal-article" @default.
- W2004394004 hasAuthorship W2004394004A5011538792 @default.
- W2004394004 hasAuthorship W2004394004A5027056624 @default.
- W2004394004 hasAuthorship W2004394004A5036980881 @default.
- W2004394004 hasAuthorship W2004394004A5047204004 @default.
- W2004394004 hasAuthorship W2004394004A5064264902 @default.
- W2004394004 hasAuthorship W2004394004A5066673105 @default.
- W2004394004 hasAuthorship W2004394004A5067653900 @default.
- W2004394004 hasAuthorship W2004394004A5069777709 @default.
- W2004394004 hasBestOaLocation W20043940041 @default.
- W2004394004 hasConcept C10205521 @default.
- W2004394004 hasConcept C121608353 @default.
- W2004394004 hasConcept C126322002 @default.
- W2004394004 hasConcept C142724271 @default.
- W2004394004 hasConcept C143998085 @default.
- W2004394004 hasConcept C167734588 @default.
- W2004394004 hasConcept C170493617 @default.
- W2004394004 hasConcept C204232928 @default.