FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004394105> ?p ?o ?g. }

• W2004394105 endingPage "13" @default.
• W2004394105 startingPage "1" @default.
• W2004394105 abstract "Phyllanthus is a traditional medicinal plant that has been found to have antihepatitis, antibacterial, and anticancer properties. The present studies were to investigate the in vitro molecular mechanisms of anticancer effects of Phyllanthus ( P. amarus, P. niruri, P. urinaria, and P. watsonii ) plant extracts in human prostate adenocarcinoma. The cancer ten-pathway reporter array was performed and revealed that the expression of six pathway reporters were significantly decreased (Wnt, NF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B, Myc/Max, hypoxia, MAPK/ERK, and MAPK/JNK) in PC-3 cells after treatment with Phyllanthus extracts. Western blot was conducted and identified several signalling molecules that were affected in the signalling pathways including pan-Ras, c-Raf, RSK, Elk1, c-Jun, JNK1/2, p38 MAPK, c-myc, DSH,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>-catenin, Akt, HIF-1<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>, GSK3<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>, NF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B p50 and p52, Bcl-2, Bax, and VEGF, in treated PC-3 cells. A proteomics-based approach, 2D gel electrophoresis, was performed, and mass spectrometry (MS/MS) results revealed that there were 72 differentially expressed proteins identified in treated PC-3 cells and were involved in tumour cell adhesion, apoptosis, glycogenesis and glycolysis, metastasis, angiogenesis, and protein synthesis and energy metabolism. Overall, these findings suggest that Phyllanthus can interfere with multiple signalling cascades involved in tumorigenesis and be used as a potential therapeutic candidate for treatment of cancer." @default.
• W2004394105 created "2016-06-24" @default.
• W2004394105 creator A5036849938 @default.
• W2004394105 creator A5037953789 @default.
• W2004394105 creator A5079062957 @default.
• W2004394105 creator A5081055159 @default.
• W2004394105 date "2013-01-01" @default.
• W2004394105 modified "2023-10-15" @default.
• W2004394105 title "<i>Phyllanthus</i>Suppresses Prostate Cancer Cell, PC-3, Proliferation and Induces Apoptosis through Multiple Signalling Pathways (MAPKs, PI3K/Akt, NF<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi mathvariant=bold>κ</mml:mi></mml:mrow></mml:math>B, and Hypoxia)" @default.
• W2004394105 cites W1517801548 @default.
• W2004394105 cites W1870720170 @default.
• W2004394105 cites W1971794516 @default.
• W2004394105 cites W1978430039 @default.
• W2004394105 cites W1980782263 @default.
• W2004394105 cites W1984036217 @default.
• W2004394105 cites W1986199954 @default.
• W2004394105 cites W1989606460 @default.
• W2004394105 cites W1995097523 @default.
• W2004394105 cites W2000598142 @default.
• W2004394105 cites W2002933387 @default.
• W2004394105 cites W2011826559 @default.
• W2004394105 cites W2018155127 @default.
• W2004394105 cites W2025319771 @default.
• W2004394105 cites W2036461308 @default.
• W2004394105 cites W2039338526 @default.
• W2004394105 cites W2043929834 @default.
• W2004394105 cites W2044494908 @default.
• W2004394105 cites W2050502538 @default.
• W2004394105 cites W2060628991 @default.
• W2004394105 cites W2062289724 @default.
• W2004394105 cites W2087861588 @default.
• W2004394105 cites W20888715 @default.
• W2004394105 cites W2088931089 @default.
• W2004394105 cites W2097259163 @default.
• W2004394105 cites W2106787323 @default.
• W2004394105 cites W2108987359 @default.
• W2004394105 cites W2115207474 @default.
• W2004394105 cites W2117692326 @default.
• W2004394105 cites W2123408027 @default.
• W2004394105 cites W2130482724 @default.
• W2004394105 cites W2132748836 @default.
• W2004394105 cites W2143643440 @default.
• W2004394105 cites W2145123477 @default.
• W2004394105 cites W2146197063 @default.
• W2004394105 cites W2146812359 @default.
• W2004394105 cites W2150026213 @default.
• W2004394105 cites W2150066952 @default.
• W2004394105 cites W2158753973 @default.
• W2004394105 cites W2160780596 @default.
• W2004394105 cites W2161962336 @default.
• W2004394105 cites W2239090104 @default.
• W2004394105 cites W2318190615 @default.
• W2004394105 cites W4238581030 @default.
• W2004394105 cites W4241087412 @default.
• W2004394105 doi "https://doi.org/10.1155/2013/609581" @default.
• W2004394105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3652183" @default.
• W2004394105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23690850" @default.
• W2004394105 hasPublicationYear "2013" @default.
• W2004394105 type Work @default.
• W2004394105 sameAs 2004394105 @default.
• W2004394105 citedByCount "28" @default.
• W2004394105 countsByYear W20043941052012 @default.
• W2004394105 countsByYear W20043941052013 @default.
• W2004394105 countsByYear W20043941052014 @default.
• W2004394105 countsByYear W20043941052016 @default.
• W2004394105 countsByYear W20043941052017 @default.
• W2004394105 countsByYear W20043941052018 @default.
• W2004394105 countsByYear W20043941052019 @default.
• W2004394105 countsByYear W20043941052020 @default.
• W2004394105 countsByYear W20043941052021 @default.
• W2004394105 countsByYear W20043941052022 @default.
• W2004394105 countsByYear W20043941052023 @default.
• W2004394105 crossrefType "journal-article" @default.
• W2004394105 hasAuthorship W2004394105A5036849938 @default.
• W2004394105 hasAuthorship W2004394105A5037953789 @default.
• W2004394105 hasAuthorship W2004394105A5079062957 @default.
• W2004394105 hasAuthorship W2004394105A5081055159 @default.
• W2004394105 hasBestOaLocation W20043941051 @default.
• W2004394105 hasConcept C11413529 @default.
• W2004394105 hasConcept C137620995 @default.
• W2004394105 hasConcept C185592680 @default.
• W2004394105 hasConcept C190283241 @default.
• W2004394105 hasConcept C41008148 @default.
• W2004394105 hasConcept C55493867 @default.
• W2004394105 hasConcept C57074206 @default.
• W2004394105 hasConcept C62478195 @default.
• W2004394105 hasConcept C75217442 @default.
• W2004394105 hasConcept C86554907 @default.
• W2004394105 hasConceptScore W2004394105C11413529 @default.
• W2004394105 hasConceptScore W2004394105C137620995 @default.
• W2004394105 hasConceptScore W2004394105C185592680 @default.
• W2004394105 hasConceptScore W2004394105C190283241 @default.
• W2004394105 hasConceptScore W2004394105C41008148 @default.
• W2004394105 hasConceptScore W2004394105C55493867 @default.
• W2004394105 hasConceptScore W2004394105C57074206 @default.
• W2004394105 hasConceptScore W2004394105C62478195 @default.
• W2004394105 hasConceptScore W2004394105C75217442 @default.
• W2004394105 hasConceptScore W2004394105C86554907 @default.

• next