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• W2004397145 abstract "Fifteen acridone alkaloids were examined for their antiproliferative activity toward monolayers and suspension of several types of cancer and normal human cell lines. As a result, atalaphyllidine (9), 5-hydroxy-N-methylseverifoline (11), atalaphyllinine (12), and des-N-methylnoracronycine (13) showed potent antiproliferative activity against tumor cell lines, whereas they have weak cytotoxicity on normal human cell lines. The structure−activity relationship established from the results revealed that a secondary amine, hydroxyl groups at C-1 and C-5, and a prenyl group at C-2 played an important role for antiproliferative activities of the tetracyclic acridones." @default.
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• W2004397145 date "1999-03-12" @default.
• W2004397145 modified "2023-10-03" @default.
• W2004397145 title "The Antiproliferative Effect of Acridone Alkaloids on Several Cancer Cell Lines" @default.
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• W2004397145 doi "https://doi.org/10.1021/np980504z" @default.
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