FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004398416> ?p ?o ?g. }

• W2004398416 endingPage "445" @default.
• W2004398416 startingPage "437" @default.
• W2004398416 abstract "One of the major physiological roles of the neuronal voltage-gated sodium channel is to generate action potentials at the axon hillock/initial segment and to ensure propagation along myelinated or unmyelinated fibers to nerve terminal. These processes require a precise distribution of sodium channels accumulated at high density in discrete subdomains of the nerve membrane. In neurons, information relevant to ion channel trafficking and compartmentalization into sub-domains of the plasma membrane is far from being elucidated. Besides, whereas information on dendritic targeting is beginning to emerge, less is known about the mechanisms leading to the polarized distribution of proteins in axon. To obtain a better understanding of how neurons selectively target sodium channels to discrete subdomains of the nerve, we addressed the question as to whether any of the large intracellular regions of Nav1.2 contain axonal sorting and/or clustering signals. We first obtained evidence showing that addition of the cytoplasmic carboxy-terminal region of Nav1.2 restricted the distribution of a dendritic-axonal reporter protein to axons of hippocampal neurons. The analysis of mutants revealed that a di-leucine-based motif mediates chimera compartmentalization in axons and its elimination in soma and dendrites by endocytosis. The analysis of the others generated chimeras showed that the determinant conferring sodium channel clustering at the axonal initial segment is contained within the cytoplasmic loop connecting domains II-III of Nav1.2. Expression of a soluble Nav1.2 II-III linker protein led to the disorganization of endogenous sodium channels. The motif was sufficient to redirect a somatodendritic potassium channel to the axonal initial segment, a process involving association with ankyrin G. Thus, it is conceivable that concerted action of the two determinants is required for sodium channel compartmentalization in axons." @default.
• W2004398416 created "2016-06-24" @default.
• W2004398416 creator A5009970715 @default.
• W2004398416 creator A5055636971 @default.
• W2004398416 creator A5077638234 @default.
• W2004398416 creator A5086403606 @default.
• W2004398416 creator A5086756048 @default.
• W2004398416 creator A5087874511 @default.
• W2004398416 date "2003-10-01" @default.
• W2004398416 modified "2023-10-18" @default.
• W2004398416 title "Dynamic compartmentalization of the voltage-gated sodium channels in axons" @default.
• W2004398416 cites W1652102492 @default.
• W2004398416 cites W1888714757 @default.
• W2004398416 cites W1920889222 @default.
• W2004398416 cites W1978553600 @default.
• W2004398416 cites W1979334130 @default.
• W2004398416 cites W1983187084 @default.
• W2004398416 cites W1995136282 @default.
• W2004398416 cites W1996988785 @default.
• W2004398416 cites W1997220636 @default.
• W2004398416 cites W2016458470 @default.
• W2004398416 cites W2030610882 @default.
• W2004398416 cites W2045554245 @default.
• W2004398416 cites W2048773003 @default.
• W2004398416 cites W2052166953 @default.
• W2004398416 cites W2057888827 @default.
• W2004398416 cites W2060705097 @default.
• W2004398416 cites W2070691915 @default.
• W2004398416 cites W2076135679 @default.
• W2004398416 cites W2079735011 @default.
• W2004398416 cites W2080633827 @default.
• W2004398416 cites W2091842720 @default.
• W2004398416 cites W2099647795 @default.
• W2004398416 cites W2110728570 @default.
• W2004398416 cites W2115628640 @default.
• W2004398416 cites W2123591482 @default.
• W2004398416 cites W2124813164 @default.
• W2004398416 cites W2142703154 @default.
• W2004398416 cites W2148218137 @default.
• W2004398416 cites W2161396884 @default.
• W2004398416 cites W2164425582 @default.
• W2004398416 cites W73391000 @default.
• W2004398416 doi "https://doi.org/10.1016/s0248-4900(03)00091-1" @default.
• W2004398416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14597261" @default.
• W2004398416 hasPublicationYear "2003" @default.
• W2004398416 type Work @default.
• W2004398416 sameAs 2004398416 @default.
• W2004398416 citedByCount "55" @default.
• W2004398416 countsByYear W20043984162012 @default.
• W2004398416 countsByYear W20043984162014 @default.
• W2004398416 countsByYear W20043984162015 @default.
• W2004398416 countsByYear W20043984162016 @default.
• W2004398416 countsByYear W20043984162017 @default.
• W2004398416 countsByYear W20043984162019 @default.
• W2004398416 countsByYear W20043984162020 @default.
• W2004398416 countsByYear W20043984162021 @default.
• W2004398416 countsByYear W20043984162022 @default.
• W2004398416 countsByYear W20043984162023 @default.
• W2004398416 crossrefType "journal-article" @default.
• W2004398416 hasAuthorship W2004398416A5009970715 @default.
• W2004398416 hasAuthorship W2004398416A5055636971 @default.
• W2004398416 hasAuthorship W2004398416A5077638234 @default.
• W2004398416 hasAuthorship W2004398416A5086403606 @default.
• W2004398416 hasAuthorship W2004398416A5086756048 @default.
• W2004398416 hasAuthorship W2004398416A5087874511 @default.
• W2004398416 hasBestOaLocation W20043984161 @default.
• W2004398416 hasConcept C110455231 @default.
• W2004398416 hasConcept C12554922 @default.
• W2004398416 hasConcept C16744765 @default.
• W2004398416 hasConcept C169760540 @default.
• W2004398416 hasConcept C178790620 @default.
• W2004398416 hasConcept C181199279 @default.
• W2004398416 hasConcept C185592680 @default.
• W2004398416 hasConcept C190062978 @default.
• W2004398416 hasConcept C2779530196 @default.
• W2004398416 hasConcept C2779617337 @default.
• W2004398416 hasConcept C50952357 @default.
• W2004398416 hasConcept C537181965 @default.
• W2004398416 hasConcept C55493867 @default.
• W2004398416 hasConcept C86803240 @default.
• W2004398416 hasConcept C95444343 @default.
• W2004398416 hasConceptScore W2004398416C110455231 @default.
• W2004398416 hasConceptScore W2004398416C12554922 @default.
• W2004398416 hasConceptScore W2004398416C16744765 @default.
• W2004398416 hasConceptScore W2004398416C169760540 @default.
• W2004398416 hasConceptScore W2004398416C178790620 @default.
• W2004398416 hasConceptScore W2004398416C181199279 @default.
• W2004398416 hasConceptScore W2004398416C185592680 @default.
• W2004398416 hasConceptScore W2004398416C190062978 @default.
• W2004398416 hasConceptScore W2004398416C2779530196 @default.
• W2004398416 hasConceptScore W2004398416C2779617337 @default.
• W2004398416 hasConceptScore W2004398416C50952357 @default.
• W2004398416 hasConceptScore W2004398416C537181965 @default.
• W2004398416 hasConceptScore W2004398416C55493867 @default.
• W2004398416 hasConceptScore W2004398416C86803240 @default.
• W2004398416 hasConceptScore W2004398416C95444343 @default.
• W2004398416 hasIssue "7" @default.
• W2004398416 hasLocation W20043984161 @default.

• next