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• W2004398919 endingPage "1735" @default.
• W2004398919 startingPage "1729" @default.
• W2004398919 abstract "The binding of medroxyprogesterone acetate (MPA) with cytosol androgen receptors from rat pituitary and hypothalamus was studied. The pituitary and hypothalamic cytosol androgen receptors from adult castrated female rats were in vitro labeled using 3H natural (testosterone (T) and 5α-dihydrotestosterone (DHT)) and [3H]synthetic (methyltrienolone) androgens as radioligands. The [3H]androgen-receptor complexes sedimented with a coefficient of 8S in linear sucrose gradients. When incubated with an excess of radioinert MPA, specific binding was abolished indicating interaction of MPA with androgen receptors. Furthermore specific [3H]MPA-androgen cytosol receptor complexes could be identified in these neuroendocrine tissues when a post-gradient receptor labeling technique was used in the absence or presence of radioinert MPA, DHT, and triamcinolone acetonide. A study of binding kinetics disclosed that the equilibrium dissociation constant and saturation binding capacity for the MPA binder, were similar to those exhibited by DHT binding to androgen receptors in both studied tissues under identical experimental conditions. The overall results were interpreted as demonstrating that MPA interacts with cytosol steroid receptors other than those of progesterone in the rat hypothalamus and anterior pituitary. The data are consistent with MPA binding to androgen receptors." @default.
• W2004398919 created "2016-06-24" @default.
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• W2004398919 date "1983-12-01" @default.
• W2004398919 modified "2023-10-17" @default.
• W2004398919 title "Interaction of medroxyprogesterone acetate with cytosol androgen receptors in the rat hypothalamus and pituitary" @default.
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• W2004398919 doi "https://doi.org/10.1016/0022-4731(83)90350-3" @default.
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