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• W2004403864 abstract "The drug discrimination procedure in animals has been extensively utilized to model the abuse related, subjective effects of drugs in humans, but it has seldom been used to examine abused volatile inhalants like toluene. The present study sought to characterize the temporal aspects of toluene's discriminative stimulus as well assess toluene blood concentrations under identical exposure conditions. B6SJLF1/J mice were trained to discriminate 10 min of exposure to 6000 ppm inhaled toluene vapor from air. Toluene vapor concentration dependently substituted for the training exposure condition with longer exposures to equivalent concentrations producing greater substitution than shorter exposures. Toluene's discriminative stimulus effects dissipated completely by 60 min after the cessation of exposure. Injected liquid toluene dose-dependently substituted for toluene vapor as well as augmenting the discriminative stimulus effects of inhaled toluene. Toluene blood concentrations measured under several exposure conditions which produced full substitution were all nearly identical suggesting that the concentration of toluene in the animal tissues at the time of testing determined discriminative performance. These results indicate that the discriminative stimulus effects of inhaled toluene vapor are likely mediated by CNS effects rather than by its pronounced peripheral stimulus effects." @default.
• W2004403864 created "2016-06-24" @default.
• W2004403864 creator A5063255413 @default.
• W2004403864 creator A5091732232 @default.
• W2004403864 date "2009-06-01" @default.
• W2004403864 modified "2023-10-14" @default.
• W2004403864 title "Characterization of an inhaled toluene drug discrimination in mice: Effect of exposure conditions and route of administration" @default.
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• W2004403864 doi "https://doi.org/10.1016/j.pbb.2009.02.015" @default.
• W2004403864 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2790325" @default.
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