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• W2004404723 abstract "4-Hydroxynonenal (HNE) is one of the major end products of lipid peroxidation. Here we show that the exposure of murine erythroleukemia (MEL) cells to 1 microM HNE, for 10.5 h over 2 days, induces a differentiation comparable with that observed in cells exposed to DMSO for the whole experiment (7 days). The exposure of MEL cells for the same length of time demonstrates a higher degree of differentiation in HNE-treated than in DMSO-treated MEL cells. The protooncogene c-myc is down-modulated early, in HNE-induced MEL cells as well as in DMSO-treated cells. However, ornithine decarboxylase gene expression first increases and then decreases, during the lowering of the proliferation rate. These findings indicate that HNE, at a concentration physiologically found in many normal tissues and in the plasma, induces MEL cell differentiation by modulation of specific gene expression." @default.
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• W2004404723 date "2001-01-01" @default.
• W2004404723 modified "2023-10-17" @default.
• W2004404723 title "Growth inhibition and differentiation induction in murine erythroleukemia cells by 4-hydroxynonenal" @default.
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• W2004404723 doi "https://doi.org/10.1080/10715760100300521" @default.
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