FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004405145> ?p ?o ?g. }

• W2004405145 endingPage "550" @default.
• W2004405145 startingPage "544" @default.
• W2004405145 abstract "Background Lipopolysaccharide (LPS) has a deleterious effect on several organs, including the liver, and eventually leads to endotoxic shock and death. LPS-induced hepatotoxicity is characterized by disturbed intracellular redox balance and excessive reactive oxygen species (ROS) accumulation, leading to liver injury. We have shown that treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, improves survival in a murine model of LPS-induced shock, but the protective effect of SAHA against liver damage remains unknown. The goal of this study was to investigate the mechanism underlying SAHA action in murine livers. Method Male C57BL/6J mice (6–8 wk), weighing 20–25 g, were randomly divided into three groups: (A) a sham group was given isotonic sodium chloride solution (10 μL/g body weight, intraperitoneal, i.p.) with dimethyl sulfoxide (DMSO; 1 μL/g body weight, i.p.); (B) an LPS group was challenged with LPS (20 mg/kg, i.p.) dissolved in isotonic sodium chloride solution with DMSO; (C) and an LPS plus SAHA group was treated with SAHA (50 mg/kg, i.p.) dissolved in DMSO immediately after injection of LPS (20 mg/kg, i.p.). Mice were anesthetized, and their livers were harvested 6 or 24 h after injection to analyze whether SAHA affected production of ROS and activation of apoptotic proteins in the liver cells of challenged mice. Results SAHA counteracted LPS-induced production of ROS (thiobarbituric acid reactive substances and nitrite) and reversed an LPS-induced decrease in antioxidant enzyme, glutathione. SAHA also attenuated LPS-induced hepatic apoptosis. Moreover, SAHA inhibited activation of the redox-sensitive kinase, apoptosis signal-regulating kinase-1, and the mitogen-activated protein kinases, p38 and Jun N-terminal kinase. Conclusions Our data indicate, for the first time, that SAHA is capable of alleviating LPS-induced hepatotoxicity and suggest that a blockade of the upstream events required for apoptosis signal-regulating kinase-1 action may serve as a new therapeutic option in the treatment of LPS-induced inflammatory conditions." @default.
• W2004405145 created "2016-06-24" @default.
• W2004405145 creator A5012198189 @default.
• W2004405145 creator A5019012228 @default.
• W2004405145 creator A5032642797 @default.
• W2004405145 creator A5054859377 @default.
• W2004405145 creator A5057755204 @default.
• W2004405145 creator A5058961918 @default.
• W2004405145 creator A5067096193 @default.
• W2004405145 date "2015-04-01" @default.
• W2004405145 modified "2023-10-16" @default.
• W2004405145 title "Protective effect of suberoylanilide hydroxamic acid against lipopolysaccharide-induced liver damage in rodents" @default.
• W2004405145 cites W1542737599 @default.
• W2004405145 cites W1600112653 @default.
• W2004405145 cites W1602123086 @default.
• W2004405145 cites W1969268163 @default.
• W2004405145 cites W1974075993 @default.
• W2004405145 cites W1977427213 @default.
• W2004405145 cites W1983588728 @default.
• W2004405145 cites W1983761290 @default.
• W2004405145 cites W1989755066 @default.
• W2004405145 cites W1990817996 @default.
• W2004405145 cites W2020187563 @default.
• W2004405145 cites W2034580062 @default.
• W2004405145 cites W2049714772 @default.
• W2004405145 cites W2050069116 @default.
• W2004405145 cites W2057511360 @default.
• W2004405145 cites W2058137293 @default.
• W2004405145 cites W2064122617 @default.
• W2004405145 cites W2066887945 @default.
• W2004405145 cites W2075289601 @default.
• W2004405145 cites W2085384576 @default.
• W2004405145 cites W2088370850 @default.
• W2004405145 cites W2093505141 @default.
• W2004405145 cites W2094265468 @default.
• W2004405145 cites W2094745968 @default.
• W2004405145 cites W2102619095 @default.
• W2004405145 cites W2112310203 @default.
• W2004405145 cites W2143640552 @default.
• W2004405145 cites W2158720649 @default.
• W2004405145 cites W2166431193 @default.
• W2004405145 cites W2313326603 @default.
• W2004405145 cites W4230395751 @default.
• W2004405145 cites W4238581030 @default.
• W2004405145 cites W4245492773 @default.
• W2004405145 cites W72469727 @default.
• W2004405145 doi "https://doi.org/10.1016/j.jss.2014.10.056" @default.
• W2004405145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4361238" @default.
• W2004405145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25479907" @default.
• W2004405145 hasPublicationYear "2015" @default.
• W2004405145 type Work @default.
• W2004405145 sameAs 2004405145 @default.
• W2004405145 citedByCount "16" @default.
• W2004405145 countsByYear W20044051452015 @default.
• W2004405145 countsByYear W20044051452016 @default.
• W2004405145 countsByYear W20044051452017 @default.
• W2004405145 countsByYear W20044051452018 @default.
• W2004405145 countsByYear W20044051452019 @default.
• W2004405145 countsByYear W20044051452020 @default.
• W2004405145 countsByYear W20044051452021 @default.
• W2004405145 countsByYear W20044051452022 @default.
• W2004405145 crossrefType "journal-article" @default.
• W2004405145 hasAuthorship W2004405145A5012198189 @default.
• W2004405145 hasAuthorship W2004405145A5019012228 @default.
• W2004405145 hasAuthorship W2004405145A5032642797 @default.
• W2004405145 hasAuthorship W2004405145A5054859377 @default.
• W2004405145 hasAuthorship W2004405145A5057755204 @default.
• W2004405145 hasAuthorship W2004405145A5058961918 @default.
• W2004405145 hasAuthorship W2004405145A5067096193 @default.
• W2004405145 hasBestOaLocation W20044051452 @default.
• W2004405145 hasConcept C104317684 @default.
• W2004405145 hasConcept C134018914 @default.
• W2004405145 hasConcept C178790620 @default.
• W2004405145 hasConcept C181199279 @default.
• W2004405145 hasConcept C185592680 @default.
• W2004405145 hasConcept C190283241 @default.
• W2004405145 hasConcept C2776202225 @default.
• W2004405145 hasConcept C2776672577 @default.
• W2004405145 hasConcept C2778004101 @default.
• W2004405145 hasConcept C2778305200 @default.
• W2004405145 hasConcept C2778452553 @default.
• W2004405145 hasConcept C2778754761 @default.
• W2004405145 hasConcept C2780159080 @default.
• W2004405145 hasConcept C48349386 @default.
• W2004405145 hasConcept C538909803 @default.
• W2004405145 hasConcept C55493867 @default.
• W2004405145 hasConcept C64927066 @default.
• W2004405145 hasConcept C71924100 @default.
• W2004405145 hasConcept C98274493 @default.
• W2004405145 hasConceptScore W2004405145C104317684 @default.
• W2004405145 hasConceptScore W2004405145C134018914 @default.
• W2004405145 hasConceptScore W2004405145C178790620 @default.
• W2004405145 hasConceptScore W2004405145C181199279 @default.
• W2004405145 hasConceptScore W2004405145C185592680 @default.
• W2004405145 hasConceptScore W2004405145C190283241 @default.
• W2004405145 hasConceptScore W2004405145C2776202225 @default.
• W2004405145 hasConceptScore W2004405145C2776672577 @default.
• W2004405145 hasConceptScore W2004405145C2778004101 @default.

• next