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• W2004405424 abstract "Objective: To determine whether proton MRS ( 1 H-MRS) neurochemical measurements predict neuropsychological outcome of patients with traumatic brain injury (TBI). Background: Although clinical indices and conventional imaging techniques provide critical information for TBI patient triage and acute care, none accurately predicts individual patient outcome. Methods: The authors studied 14 patients with TBI soon after injury (45 ± 21 days postinjury) and again at 6 months (172 ± 43 days) and 14 age-, sex-, and education-matched control subjects. N -acetylaspartate (NAA), creatine, and choline were measured in normal-appearing occipitoparietal white and gray matter using quantitative 1 H-MRS. Outcome was assessed with the Glasgow Outcome Scale (GOS) and a battery of neuropsychological tests. A composite measure of neuropsychological function was calculated from individual test z -scores probing the major functional domains commonly impaired after head trauma. Results: Early NAA concentrations in gray matter predicted overall neuropsychological performance ( r = 0.74, p = 0.01) and GOS (F = 11.93, p = 0.007). Other metabolite measures were not related to behavioral function at outcome. Conclusion: 1 H-MRS provides a rapid, noninvasive tool to assess the extent of diffuse injury after head trauma, a component of injury that may be the most critical factor in evaluating resultant neuropsychological dysfunction. 1 H-MRS can be added to conventional MR examinations with minimal additional time, and may prove useful in assessing injury severity, guiding patient care, and predicting patient outcome." @default.
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• W2004405424 date "1999-04-01" @default.
• W2004405424 modified "2023-10-15" @default.
• W2004405424 title "Quantitative proton MRS predicts outcome after traumatic brain injury" @default.
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• W2004405424 doi "https://doi.org/10.1212/wnl.52.7.1384" @default.
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