FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004407425> ?p ?o ?g. }

• W2004407425 endingPage "303" @default.
• W2004407425 startingPage "297" @default.
• W2004407425 abstract "Objective Idiopathic normal pressure hydrocephalus (iNPH) is clinically important as a treatable gait disturbance or preventable dementia by shunt operation. We have recently reported that approximately 1.5% of the elderly living in a Japanese community showed ventriculomegaly with features of iNPH on MRI (VIM), which may represent a preclinical stage of iNPH. The purpose of the present study was to identify a possible genetic change in VIM subjects. Methods Eight subjects with VIM and 10 healthy individuals were examined for copy number variations (CNV) with a CNV-targeted whole-genome oligonucleotide microarray (Agilent 400 K CNV array). Another panel of 100 healthy Japanese individuals was screened for CNV by whole-genome using the deCODE-Illumina CNV 370 K chip. Immunohistochemical examination of the human brain was performed using an avidin-biotin-peroxidase complex method. Results Among several genetic changes observed, a copy number loss within the SFMBT1 gene was seen in half of the VIM cases (4 of 8 cases), that was rare among the Japanese control subjects (0/10 by Agilent 400 K CNV array or 1/100 by deCODE/Illumina CNV 370 K chip). Immunohistochemical examination of the human brain revealed that the SFMBT1 protein was localized mainly in the arterial walls, the ependymal cells, and the epithelium of the choroid plexus, all of which play a crucial role in the CSF circulation. Conclusion A segmental copy number loss of the SFMBT1 gene may be involved in the pathological process in some individuals with VIM/iNPH." @default.
• W2004407425 created "2016-06-24" @default.
• W2004407425 creator A5009546157 @default.
• W2004407425 creator A5015711180 @default.
• W2004407425 creator A5041503950 @default.
• W2004407425 creator A5051575733 @default.
• W2004407425 creator A5055175958 @default.
• W2004407425 creator A5066458898 @default.
• W2004407425 creator A5077019817 @default.
• W2004407425 creator A5083461231 @default.
• W2004407425 creator A5088941541 @default.
• W2004407425 date "2011-01-01" @default.
• W2004407425 modified "2023-10-05" @default.
• W2004407425 title "Segmental Copy Number Loss of SFMBT1 Gene in Elderly Individuals with Ventriculomegaly: A Community-Based Study" @default.
• W2004407425 cites W1966321968 @default.
• W2004407425 cites W1997031801 @default.
• W2004407425 cites W1997588694 @default.
• W2004407425 cites W2000992854 @default.
• W2004407425 cites W2003873323 @default.
• W2004407425 cites W2021714239 @default.
• W2004407425 cites W2028067282 @default.
• W2004407425 cites W2030324463 @default.
• W2004407425 cites W2031117768 @default.
• W2004407425 cites W2035351412 @default.
• W2004407425 cites W2047361940 @default.
• W2004407425 cites W2053101516 @default.
• W2004407425 cites W2065309780 @default.
• W2004407425 cites W2071026538 @default.
• W2004407425 cites W2071926124 @default.
• W2004407425 cites W2074074428 @default.
• W2004407425 cites W2086259640 @default.
• W2004407425 cites W2087261765 @default.
• W2004407425 cites W2093396457 @default.
• W2004407425 cites W2116034738 @default.
• W2004407425 cites W2129637418 @default.
• W2004407425 cites W2133174470 @default.
• W2004407425 cites W2139662943 @default.
• W2004407425 cites W2144644150 @default.
• W2004407425 cites W2144974645 @default.
• W2004407425 cites W2149681218 @default.
• W2004407425 cites W2151751911 @default.
• W2004407425 cites W2155707112 @default.
• W2004407425 cites W4246506616 @default.
• W2004407425 cites W66532333 @default.
• W2004407425 doi "https://doi.org/10.2169/internalmedicine.50.4505" @default.
• W2004407425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21325761" @default.
• W2004407425 hasPublicationYear "2011" @default.
• W2004407425 type Work @default.
• W2004407425 sameAs 2004407425 @default.
• W2004407425 citedByCount "26" @default.
• W2004407425 countsByYear W20044074252012 @default.
• W2004407425 countsByYear W20044074252014 @default.
• W2004407425 countsByYear W20044074252016 @default.
• W2004407425 countsByYear W20044074252017 @default.
• W2004407425 countsByYear W20044074252018 @default.
• W2004407425 countsByYear W20044074252019 @default.
• W2004407425 countsByYear W20044074252020 @default.
• W2004407425 countsByYear W20044074252022 @default.
• W2004407425 countsByYear W20044074252023 @default.
• W2004407425 crossrefType "journal-article" @default.
• W2004407425 hasAuthorship W2004407425A5009546157 @default.
• W2004407425 hasAuthorship W2004407425A5015711180 @default.
• W2004407425 hasAuthorship W2004407425A5041503950 @default.
• W2004407425 hasAuthorship W2004407425A5051575733 @default.
• W2004407425 hasAuthorship W2004407425A5055175958 @default.
• W2004407425 hasAuthorship W2004407425A5066458898 @default.
• W2004407425 hasAuthorship W2004407425A5077019817 @default.
• W2004407425 hasAuthorship W2004407425A5083461231 @default.
• W2004407425 hasAuthorship W2004407425A5088941541 @default.
• W2004407425 hasBestOaLocation W20044074251 @default.
• W2004407425 hasConcept C104317684 @default.
• W2004407425 hasConcept C120821319 @default.
• W2004407425 hasConcept C126322002 @default.
• W2004407425 hasConcept C141231307 @default.
• W2004407425 hasConcept C142724271 @default.
• W2004407425 hasConcept C150194340 @default.
• W2004407425 hasConcept C172680121 @default.
• W2004407425 hasConcept C186836561 @default.
• W2004407425 hasConcept C2776212519 @default.
• W2004407425 hasConcept C2776538271 @default.
• W2004407425 hasConcept C2779134260 @default.
• W2004407425 hasConcept C2779234561 @default.
• W2004407425 hasConcept C2779483572 @default.
• W2004407425 hasConcept C529278444 @default.
• W2004407425 hasConcept C54355233 @default.
• W2004407425 hasConcept C71924100 @default.
• W2004407425 hasConcept C86803240 @default.
• W2004407425 hasConceptScore W2004407425C104317684 @default.
• W2004407425 hasConceptScore W2004407425C120821319 @default.
• W2004407425 hasConceptScore W2004407425C126322002 @default.
• W2004407425 hasConceptScore W2004407425C141231307 @default.
• W2004407425 hasConceptScore W2004407425C142724271 @default.
• W2004407425 hasConceptScore W2004407425C150194340 @default.
• W2004407425 hasConceptScore W2004407425C172680121 @default.
• W2004407425 hasConceptScore W2004407425C186836561 @default.
• W2004407425 hasConceptScore W2004407425C2776212519 @default.
• W2004407425 hasConceptScore W2004407425C2776538271 @default.
• W2004407425 hasConceptScore W2004407425C2779134260 @default.

• next