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• W2004409500 abstract "The management of thrombotic conditions, hypercoagulable states, and anticoagulant therapy in pregnant women remains a clinical challenge. Pulmonary embolism (PE) continues to be the leading cause of maternal mortality in the Western world [ 1 Confidential Enquiries into Maternal and Child Health. Why mothers die: 2000–2002. The Sixth Report of the UK confidential Enquiries into Maternal Deaths. 2004, London: The Royal College of Obstetricians and Gynaecologists Press; November 2004. Google Scholar , 2 Confidential Enquiries into Maternal and Child Health (CEMACH). Saving mothers' lives: reviewing maternal deaths to make motherhood safer — 2003–2005. The Seventh Report of the UK Confidential Enquiries into Maternal Deaths in the United Kingdom. London: CEMACH; 2007. Google Scholar , 3 Chang J Elam-Evans LD Berg CJ Hendon J Flowers L Seed KA et al. Pregnancy-related mortality surveillance: United States, 1991–1999. MMWR Surveill Summ. 2003; 52: 1-8 PubMed Google Scholar , 4 James AH Jamison MG Brancazio LR Myers MR Venous thromboembolism during pregnancy and the post-partum period: incidence, risk factors, and mortality. Am J Obstet Gynecol. 2006; 194: 1311-1315 Abstract Full Text Full Text PDF PubMed Scopus (667) Google Scholar ] and venous thromboembolism (VTE) in pregnancy is an important cause of maternal morbidity [ 5 McColl MD Ellison J Greer IA Tait RC Walker ID Prevention of the post-thrombotic syndrome in young women with previous venous thromboembolism. Br J Haematol. 2000; 108: 272-274 Crossref PubMed Scopus (77) Google Scholar ]. Pregnant women with mechanical heart valves also appear to be at particularly high risk for thromboembolic events, with reported incidences as high as 60% [ 6 Chan WS Anand SS Ginsberg JS Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med. 2000; 160: 191-196 Crossref PubMed Scopus (613) Google Scholar ]. Many such events present as valve thrombosis, which is associated with mortality rates ranging from 30% to 67% [ 7 James AH Brancazio LR Gehrig TR Wang A Ortel TL Low-molecular-weight heparin thromboprophylaxis in pregnant women with mechanical heart valves. J Matern Fetal Neonatal Med. 2006; 19: 543-549 Crossref PubMed Scopus (51) Google Scholar ]. The use of anticoagulant therapy during pregnancy is also problematic because of the potential for fetal, as well as maternal, complications. Finally, the amount of high quality data upon which to base management decisions in this patient population is limited, with the majority of published reports consisting of uncontrolled studies or case series. Indeed, even when controlled studies are available, they often have important methodological limitations." @default.
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• W2004409500 date "2009-01-01" @default.
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• W2004409500 title "North American and British guidelines for anti-thrombotic therapy: are we reaching consensus?" @default.
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• W2004409500 doi "https://doi.org/10.1016/s0049-3848(09)70023-4" @default.
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