FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004413331> ?p ?o ?g. }

• W2004413331 endingPage "285212" @default.
• W2004413331 startingPage "285212" @default.
• W2004413331 abstract "For the vast majority of naturally occurring, small, single-domain proteins, folding is often described as a two-state process that lacks detectable intermediates. This observation has often been rationalized on the basis of a nucleation mechanism for protein folding whose basic premise is the idea that, after completion of a specific set of contacts forming the so-called folding nucleus, the native state is achieved promptly. Here we propose a methodology to identify folding nuclei in small lattice polymers and apply it to the study of protein molecules with a chain length of N = 48. To investigate the extent to which protein topology is a robust determinant of the nucleation mechanism, we compare the nucleation scenario of a native-centric model with that of a sequence-specific model sharing the same native fold. To evaluate the impact of the sequence's finer details in the nucleation mechanism, we consider the folding of two non-homologous sequences. We conclude that, in a sequence-specific model, the folding nucleus is, to some extent, formed by the most stable contacts in the protein and that the less stable linkages in the folding nucleus are solely determined by the fold's topology. We have also found that, independently of the protein sequence, the folding nucleus performs the same 'topological' function. This unifying feature of the nucleation mechanism results from the residues forming the folding nucleus being distributed along the protein chain in a similar and well-defined manner that is determined by the fold's topological features." @default.
• W2004413331 created "2016-06-24" @default.
• W2004413331 creator A5049972739 @default.
• W2004413331 creator A5052906833 @default.
• W2004413331 creator A5072261174 @default.
• W2004413331 date "2007-06-25" @default.
• W2004413331 modified "2023-10-15" @default.
• W2004413331 title "Nucleation phenomena in protein folding: the modulating role of protein sequence" @default.
• W2004413331 cites W1535462036 @default.
• W2004413331 cites W1536428180 @default.
• W2004413331 cites W1968528812 @default.
• W2004413331 cites W1969607952 @default.
• W2004413331 cites W1973473385 @default.
• W2004413331 cites W1974105492 @default.
• W2004413331 cites W1975017420 @default.
• W2004413331 cites W1982723866 @default.
• W2004413331 cites W1987451605 @default.
• W2004413331 cites W1988690429 @default.
• W2004413331 cites W1989297730 @default.
• W2004413331 cites W1989300794 @default.
• W2004413331 cites W2000596121 @default.
• W2004413331 cites W2005865331 @default.
• W2004413331 cites W2016019576 @default.
• W2004413331 cites W2025127982 @default.
• W2004413331 cites W2025142768 @default.
• W2004413331 cites W2027465657 @default.
• W2004413331 cites W2043391129 @default.
• W2004413331 cites W2047935897 @default.
• W2004413331 cites W2049558868 @default.
• W2004413331 cites W2049966629 @default.
• W2004413331 cites W2055118532 @default.
• W2004413331 cites W2056760934 @default.
• W2004413331 cites W2056887931 @default.
• W2004413331 cites W2063870542 @default.
• W2004413331 cites W2072843928 @default.
• W2004413331 cites W2074848217 @default.
• W2004413331 cites W2078088251 @default.
• W2004413331 cites W2081733850 @default.
• W2004413331 cites W2085720059 @default.
• W2004413331 cites W2089597488 @default.
• W2004413331 cites W2090304431 @default.
• W2004413331 cites W2092637963 @default.
• W2004413331 cites W2104704906 @default.
• W2004413331 cites W2128954946 @default.
• W2004413331 cites W2130949317 @default.
• W2004413331 cites W2145010489 @default.
• W2004413331 cites W2165890129 @default.
• W2004413331 cites W2167690037 @default.
• W2004413331 cites W3104305066 @default.
• W2004413331 cites W4295224975 @default.
• W2004413331 doi "https://doi.org/10.1088/0953-8984/19/28/285212" @default.
• W2004413331 hasPublicationYear "2007" @default.
• W2004413331 type Work @default.
• W2004413331 sameAs 2004413331 @default.
• W2004413331 citedByCount "4" @default.
• W2004413331 crossrefType "journal-article" @default.
• W2004413331 hasAuthorship W2004413331A5049972739 @default.
• W2004413331 hasAuthorship W2004413331A5052906833 @default.
• W2004413331 hasAuthorship W2004413331A5072261174 @default.
• W2004413331 hasConcept C119599485 @default.
• W2004413331 hasConcept C12554922 @default.
• W2004413331 hasConcept C127413603 @default.
• W2004413331 hasConcept C178790620 @default.
• W2004413331 hasConcept C185592680 @default.
• W2004413331 hasConcept C204328495 @default.
• W2004413331 hasConcept C2776545253 @default.
• W2004413331 hasConcept C2778112365 @default.
• W2004413331 hasConcept C55493867 @default.
• W2004413331 hasConcept C61048295 @default.
• W2004413331 hasConcept C70721500 @default.
• W2004413331 hasConcept C8010536 @default.
• W2004413331 hasConcept C86803240 @default.
• W2004413331 hasConceptScore W2004413331C119599485 @default.
• W2004413331 hasConceptScore W2004413331C12554922 @default.
• W2004413331 hasConceptScore W2004413331C127413603 @default.
• W2004413331 hasConceptScore W2004413331C178790620 @default.
• W2004413331 hasConceptScore W2004413331C185592680 @default.
• W2004413331 hasConceptScore W2004413331C204328495 @default.
• W2004413331 hasConceptScore W2004413331C2776545253 @default.
• W2004413331 hasConceptScore W2004413331C2778112365 @default.
• W2004413331 hasConceptScore W2004413331C55493867 @default.
• W2004413331 hasConceptScore W2004413331C61048295 @default.
• W2004413331 hasConceptScore W2004413331C70721500 @default.
• W2004413331 hasConceptScore W2004413331C8010536 @default.
• W2004413331 hasConceptScore W2004413331C86803240 @default.
• W2004413331 hasIssue "28" @default.
• W2004413331 hasLocation W20044133311 @default.
• W2004413331 hasOpenAccess W2004413331 @default.
• W2004413331 hasPrimaryLocation W20044133311 @default.
• W2004413331 hasRelatedWork W1964794469 @default.
• W2004413331 hasRelatedWork W1970708927 @default.
• W2004413331 hasRelatedWork W1974970687 @default.
• W2004413331 hasRelatedWork W2008935619 @default.
• W2004413331 hasRelatedWork W2016081971 @default.
• W2004413331 hasRelatedWork W2072516324 @default.
• W2004413331 hasRelatedWork W2334410912 @default.
• W2004413331 hasRelatedWork W2912565574 @default.
• W2004413331 hasRelatedWork W3107021667 @default.

• next