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• W2004413463 abstract "The goal of part I of this study was to evaluate the effects of whole-body proton irradiation on lymphoid organs and specific leukocyte populations. C57BL/6 mice were exposed to the entry region of the proton Bragg curve to total doses of 0.5 gray (Gy), 1.5 Gy, and 3.0 Gy, each delivered at a low dose rate (LDR) of 1 cGy/min and high dose rate (HDR) of 80 cGy/min. Non-irradiated and 3 Gy HDR γ-irradiated groups were included as controls. At 4 days post-irradiation, highly significant radiation dose-dependent reductions were observed in the mass of both lymphoid organs and the numbers of leukocytes and T (CD3+), T helper (CD3+/CD4+), T cytotoxic (CD3+/CD8+), and B (CD19+) cells in both blood and spleen. A less pronounced dose effect was noted for natural killer (NK1.1+ NK) cells in spleen. Monocyte, but not granulocyte, counts in blood were highly dose-dependent. The numbers for each population generally tended to be lower with HDR than with LDR radiation; a significant dose rate effect was found in the percentages of T and B cells, monocytes, and granulocytes and in CD4+:CD8+ ratios. These data indicate that mononuclear cell response to the entry region of the proton Bragg curve is highly dependent upon the total dose and that dose rate effects are evident with some cell types. Results from γ- and proton-irradiated groups (both at 3 Gy HDR) were similar, although proton-irradiation gave consistently lower values in some measurements." @default.
• W2004413463 created "2016-06-24" @default.
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• W2004413463 date "2002-01-01" @default.
• W2004413463 modified "2023-10-18" @default.
• W2004413463 title "Dose and dose rate effects of whole-body proton irradiation on leukocyte populations and lymphoid organs: Part I" @default.
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• W2004413463 doi "https://doi.org/10.1016/s0165-2478(01)00306-6" @default.
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