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• W2004435858 abstract "Site-specific labeling of RNA molecules is a valuable tool for studying their structure and function. Here, we describe a new site-specific RNA labeling method, which utilizes a DNA-templated chemical reaction to attach a label at a specific internal nucleotide in an RNA molecule. The method is nonenzymatic and based on the formation of a four-way junction, where a donor strand is chemically coupled to an acceptor strand at a specific position via an activated chemical group. A disulfide bond in the linker is subsequently cleaved under mild conditions leaving a thiol group attached to the acceptor-RNA strand. The site-specific thiol-modified target RNA can then be chemically labeled with an optional group, here demonstrated by coupling of a maleimide-functionalized fluorophore. The method is rapid and allows site specific labeling of both in vitro and in vivo synthesized RNA with a broad range of functional groups." @default.
• W2004435858 created "2016-06-24" @default.
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• W2004435858 date "2010-12-07" @default.
• W2004435858 modified "2023-10-18" @default.
• W2004435858 title "Site-Specific Chemical Labeling of Long RNA Molecules" @default.
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• W2004435858 doi "https://doi.org/10.1021/bc100422k" @default.
• W2004435858 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21138255" @default.
• W2004435858 hasPublicationYear "2010" @default.
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