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• W2004448768 abstract "Alterations in the function of the hypothalamic suprachiasmatic nucleus (SCN) with age have been reported. As serotonin is an important regulator of the circadian clock located in SCN, this work studied the changes produced in the synthesis of serotonin with age using the accumulation of 5-HTP after decarboxylase inhibition as a measure of serotonin synthesis in the brain in vivo, in young and old ring doves at the onset of lights-on and lights-off. A diurnal cycle in tryptophan hydroxylation was observed in young animals, with an increased daylight synthesis and metabolism of 5-HT in hippocampus, neostriatum and hypothalamus. A single dose of melatonin (1 mg/kg, i.p., 1 h) at lighttime produced an inhibitory effect on the synthesis of 5-HT. In contrast, differences in 5-HT synthesis and metabolism between day and night disappeared in old animals indicating an absence of a circadian rhythm in 5-HT synthesis and metabolism. The administration of L-tryptophan (240 mg/kg, i.p.) strongly increased the 5-HT synthesis in young animals only during lights-off time while it increased in old ones irrespective of the administration time. These results suggest that the supplemental administration of tryptophan might aid to improve the descent in 5-HT that normally occurs, as animals get old." @default.
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• W2004448768 date "2006-01-01" @default.
• W2004448768 modified "2023-09-30" @default.
• W2004448768 title "Age-related changes in circadian rhythm of serotonin synthesis in ring doves: Effects of increased tryptophan ingestion" @default.
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• W2004448768 doi "https://doi.org/10.1016/j.exger.2005.09.010" @default.
• W2004448768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16271444" @default.
• W2004448768 hasPublicationYear "2006" @default.
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