FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004451483> ?p ?o ?g. }

• W2004451483 endingPage "1390" @default.
• W2004451483 startingPage "1385" @default.
• W2004451483 abstract "Abstract Testosterone (T) and dihydrotestosterone (DHT) were found to bind to a specific protein in genital skin fibroblasts of a patient with 5α-reductase deficiency. While maximum number of binding sites ( B max ) were similar for both androgens, the apparent dissociation constant ( K D ) of the androgen receptor for T was somewhat greater than for DHT. In competition studies of [ 3 H]-T bound to the receptor with unlabeled T or DHT, the inhibitor constant ( K i ) for T was two to three fold greater than the K i for DHT. Also, the dissociation rate constant ( k D ) for [ 3 H]-T bound to the receptor was greater than for [ 3 H]-DHT ( t 1 2 for T = 10 h and t 1 2 for DHT = 74.5 h). These results suggest that T may play a role in the sexual differentiation of male patients with 5α-reductase deficiency during their fetal life and at puberty. The low degree of masculinization during fetal life would be explained by the lower affinity and faster turnover rate of the T-reeeptor complex relative to the DHT-receptor complex. The relatively greater masculinization observed at puberty would be explained by the higher plasma T levels attained in the adult when compared to the fetus." @default.
• W2004451483 created "2016-06-24" @default.
• W2004451483 creator A5018575728 @default.
• W2004451483 creator A5031632319 @default.
• W2004451483 creator A5031912069 @default.
• W2004451483 creator A5067751371 @default.
• W2004451483 creator A5068016480 @default.
• W2004451483 date "1979-10-01" @default.
• W2004451483 modified "2023-09-26" @default.
• W2004451483 title "Role of testosterone binding to the androgen receptor in male sexual differentiation of patients with 5α-reductase deficiency" @default.
• W2004451483 cites W1508135135 @default.
• W2004451483 cites W1573981241 @default.
• W2004451483 cites W1885778179 @default.
• W2004451483 cites W1906197854 @default.
• W2004451483 cites W1970119940 @default.
• W2004451483 cites W1980967604 @default.
• W2004451483 cites W1981318616 @default.
• W2004451483 cites W1983649348 @default.
• W2004451483 cites W1992103956 @default.
• W2004451483 cites W2004532906 @default.
• W2004451483 cites W2005005204 @default.
• W2004451483 cites W2011396297 @default.
• W2004451483 cites W2012642233 @default.
• W2004451483 cites W2032475605 @default.
• W2004451483 cites W2049441749 @default.
• W2004451483 cites W2052887619 @default.
• W2004451483 cites W2084376281 @default.
• W2004451483 cites W2091484792 @default.
• W2004451483 cites W2094869444 @default.
• W2004451483 cites W2135957877 @default.
• W2004451483 cites W2202263696 @default.
• W2004451483 cites W2315466245 @default.
• W2004451483 cites W2317511325 @default.
• W2004451483 doi "https://doi.org/10.1016/0022-4731(79)90110-9" @default.
• W2004451483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/513759" @default.
• W2004451483 hasPublicationYear "1979" @default.
• W2004451483 type Work @default.
• W2004451483 sameAs 2004451483 @default.
• W2004451483 citedByCount "45" @default.
• W2004451483 countsByYear W20044514832013 @default.
• W2004451483 countsByYear W20044514832015 @default.
• W2004451483 countsByYear W20044514832019 @default.
• W2004451483 countsByYear W20044514832020 @default.
• W2004451483 countsByYear W20044514832021 @default.
• W2004451483 crossrefType "journal-article" @default.
• W2004451483 hasAuthorship W2004451483A5018575728 @default.
• W2004451483 hasAuthorship W2004451483A5031632319 @default.
• W2004451483 hasAuthorship W2004451483A5031912069 @default.
• W2004451483 hasAuthorship W2004451483A5067751371 @default.
• W2004451483 hasAuthorship W2004451483A5068016480 @default.
• W2004451483 hasConcept C104317684 @default.
• W2004451483 hasConcept C121608353 @default.
• W2004451483 hasConcept C126322002 @default.
• W2004451483 hasConcept C134018914 @default.
• W2004451483 hasConcept C185592680 @default.
• W2004451483 hasConcept C2777911890 @default.
• W2004451483 hasConcept C2779279991 @default.
• W2004451483 hasConcept C2779665388 @default.
• W2004451483 hasConcept C2780192828 @default.
• W2004451483 hasConcept C54355233 @default.
• W2004451483 hasConcept C61367390 @default.
• W2004451483 hasConcept C63405245 @default.
• W2004451483 hasConcept C71315377 @default.
• W2004451483 hasConcept C71924100 @default.
• W2004451483 hasConcept C86803240 @default.
• W2004451483 hasConceptScore W2004451483C104317684 @default.
• W2004451483 hasConceptScore W2004451483C121608353 @default.
• W2004451483 hasConceptScore W2004451483C126322002 @default.
• W2004451483 hasConceptScore W2004451483C134018914 @default.
• W2004451483 hasConceptScore W2004451483C185592680 @default.
• W2004451483 hasConceptScore W2004451483C2777911890 @default.
• W2004451483 hasConceptScore W2004451483C2779279991 @default.
• W2004451483 hasConceptScore W2004451483C2779665388 @default.
• W2004451483 hasConceptScore W2004451483C2780192828 @default.
• W2004451483 hasConceptScore W2004451483C54355233 @default.
• W2004451483 hasConceptScore W2004451483C61367390 @default.
• W2004451483 hasConceptScore W2004451483C63405245 @default.
• W2004451483 hasConceptScore W2004451483C71315377 @default.
• W2004451483 hasConceptScore W2004451483C71924100 @default.
• W2004451483 hasConceptScore W2004451483C86803240 @default.
• W2004451483 hasIssue "4" @default.
• W2004451483 hasLocation W20044514831 @default.
• W2004451483 hasLocation W20044514832 @default.
• W2004451483 hasOpenAccess W2004451483 @default.
• W2004451483 hasPrimaryLocation W20044514831 @default.
• W2004451483 hasRelatedWork W1977493149 @default.
• W2004451483 hasRelatedWork W1979452793 @default.
• W2004451483 hasRelatedWork W1981433740 @default.
• W2004451483 hasRelatedWork W1986311037 @default.
• W2004451483 hasRelatedWork W2004261902 @default.
• W2004451483 hasRelatedWork W2053247908 @default.
• W2004451483 hasRelatedWork W2083564258 @default.
• W2004451483 hasRelatedWork W2089368232 @default.
• W2004451483 hasRelatedWork W2103250319 @default.
• W2004451483 hasRelatedWork W2143079083 @default.
• W2004451483 hasVolume "11" @default.
• W2004451483 isParatext "false" @default.
• W2004451483 isRetracted "false" @default.

• next