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• W2004452254 abstract "Abstract Recessive lethal mutations are induced by UV light in Drosophila oogonia by irradiating in vitro ovary primordia which afterwards are implanted into host larvae. A constant dose of 2000 ergs/mm2 is used with the following 3 methods of irradiation: (a)The whole does is given at once in one direction (control). (b) The dose is given in 2 halves separated by a 2-h interval without change of direction. (c) Half of the dose is given in one direction and the other half in the opposite direction. As compared with the control, method (b) leads to a decrease both in the maturation frequency and in the absolute size of the cluster of identical lethals. Method ((c) leads to an increase in the mutation frequency and a decrease in both the probability of success of the implantation and the size of the total progeny produced by the implanted ovary. Differences between effects after treatment according to (c) and the control favour the assumption that the different cell layers of the primordium do not receive the same amount of radiation. At high doses the recovered eggs tend to arise only from the less damaged oogonia. This mechanisms can account for part of the decrease in the frequency of recovered mutations which is observed at high doses. Differences between the effects after treatment according to (b) and the control point to an additional mechanism. The correlation between the size of the clusters and the mutation frequency which is obtained is quite general. It is also observed when high and low doses are compared. The reduction of cluster size is probably the outcome of a delay imposed by the irradiation on the resumption of DNA synthesis. With this delay, the probability that premutational lesions undergo “dark repair” is increased." @default.
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• W2004452254 date "1967-07-01" @default.
• W2004452254 modified "2023-10-01" @default.
• W2004452254 title "Action mutagène des UV sur les ovogonies de drosophiles II. Effets du double éclairement et du fractionnement sur le pourcentage de mutations" @default.
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• W2004452254 doi "https://doi.org/10.1016/0027-5107(67)90011-5" @default.
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