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• W2004454319 endingPage "307" @default.
• W2004454319 startingPage "301" @default.
• W2004454319 abstract "During folding of the embryo, lateroanterior visceral mesoderm forms the embryonic tubular heart at the midline, just ventral to the foregut. In mice, this nascent tube contains the future left ventricle and atrioventricular canal. Mesenchymal cells subsequently recruited to the cardiac lineage at the intake and the outflow of the tube will form the atria and the right ventricle and outflow tract, respectively. Shortly after its emergence, the embryonic heart tube starts to loop, and the first signs of left ventricular chamber differentiation become visible on the outer curvature of the middle portion of the tube. Subsequently, the right ventricle differentiates cranially, and the atria caudally, while the inflow tract, atrioventricular canal, inner curvatures, and outflow tract form recognizable components flanking the chambers. The latter, nonchamber regions in turn provide signals for the formation of the cushion mesenchyme, are involved in remodeling of the heart, and form the nodes of the conduction system. This review discusses how the patterning of the heart tube relates to the localized differentiation of atrial and ventricular chambers, why some parts of the heart do not form chambers, and how this relates to the formation of the conduction system." @default.
• W2004454319 created "2016-06-24" @default.
• W2004454319 creator A5002005916 @default.
• W2004454319 creator A5024997012 @default.
• W2004454319 creator A5068204184 @default.
• W2004454319 date "2004-11-01" @default.
• W2004454319 modified "2023-09-27" @default.
• W2004454319 title "Architectural Plan for the Heart: Early Patterning and Delineation of the Chambers and the Nodes" @default.
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• W2004454319 doi "https://doi.org/10.1016/j.tcm.2004.09.002" @default.
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