FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004455417> ?p ?o ?g. }

• W2004455417 endingPage "794" @default.
• W2004455417 startingPage "788" @default.
• W2004455417 abstract "Cystathionine γ-lyase (CSE) is an enzyme catalyzing cystathionine and cysteine to yield cysteine and hydrogen sulfide (H2S), respectively. This study aimed to examine if H2S generated from the enzyme could serve as an endogenous regulator of hepatobiliary function. Gas chromatographic analyses indicated that, among rat organs herein examined, liver constituted one of the greatest components of H2S generation in the body, at 100 μmol/g of tissue, comparable to that in kidney and 1.5-fold greater than that in brain, where roles of the gas in the regulation of neurotransmission were reported previously. At least half of the gas amount in the liver appeared to be derived from CSE, because blockade of the enzyme by propargylglycine suppressed it by 50%. Immunohistochemistry revealed that CSE occurs not only in hepatocytes, but also in bile duct. In livers in vivo, as well as in those perfused ex vivo, treatment with the CSE inhibitor induced choleresis by stimulating the basal excretion of bicarbonate in bile samples. Transportal supplementation of NaHS at 30 μmol/L, but not that of N-acetylcysteine as a cysteine donor, abolished these changes elicited by the CSE inhibitor in the perfused liver. The changes elicited by the CSE blockade did not coincide with alterations in hepatic vascular resistance, showing little involvement of vasodilatory effects of the gas in these events, if any. These results first provided evidence that H2S generated through CSE modulates biliary bicarbonate excretion and is thus a determinant of bile salt-independent bile formation in the rat liver.Antioxid. Redox Signal. 7, 788–794." @default.
• W2004455417 created "2016-06-24" @default.
• W2004455417 creator A5020354238 @default.
• W2004455417 creator A5024663537 @default.
• W2004455417 creator A5030974936 @default.
• W2004455417 creator A5031280081 @default.
• W2004455417 creator A5038654766 @default.
• W2004455417 creator A5049429446 @default.
• W2004455417 creator A5084473935 @default.
• W2004455417 creator A5087446373 @default.
• W2004455417 creator A5088897091 @default.
• W2004455417 date "2005-05-01" @default.
• W2004455417 modified "2023-09-27" @default.
• W2004455417 title "Hydrogen Sulfide as an Endogenous Modulator of Biliary Bicarbonate Excretion in the Rat Liver" @default.
• W2004455417 cites W1789963253 @default.
• W2004455417 cites W1988670957 @default.
• W2004455417 cites W1989445100 @default.
• W2004455417 cites W1989578024 @default.
• W2004455417 cites W2002429018 @default.
• W2004455417 cites W2004491334 @default.
• W2004455417 cites W2015407072 @default.
• W2004455417 cites W2016727102 @default.
• W2004455417 cites W2019541558 @default.
• W2004455417 cites W2043866017 @default.
• W2004455417 cites W2060998914 @default.
• W2004455417 cites W2066598486 @default.
• W2004455417 cites W2067011965 @default.
• W2004455417 cites W2109915311 @default.
• W2004455417 cites W2127095655 @default.
• W2004455417 cites W2137394317 @default.
• W2004455417 cites W2141610173 @default.
• W2004455417 cites W2148156463 @default.
• W2004455417 cites W2167151854 @default.
• W2004455417 cites W4319705863 @default.
• W2004455417 doi "https://doi.org/10.1089/ars.2005.7.788" @default.
• W2004455417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15890026" @default.
• W2004455417 hasPublicationYear "2005" @default.
• W2004455417 type Work @default.
• W2004455417 sameAs 2004455417 @default.
• W2004455417 citedByCount "29" @default.
• W2004455417 countsByYear W20044554172012 @default.
• W2004455417 countsByYear W20044554172013 @default.
• W2004455417 countsByYear W20044554172015 @default.
• W2004455417 countsByYear W20044554172016 @default.
• W2004455417 countsByYear W20044554172018 @default.
• W2004455417 countsByYear W20044554172020 @default.
• W2004455417 countsByYear W20044554172021 @default.
• W2004455417 countsByYear W20044554172023 @default.
• W2004455417 crossrefType "journal-article" @default.
• W2004455417 hasAuthorship W2004455417A5020354238 @default.
• W2004455417 hasAuthorship W2004455417A5024663537 @default.
• W2004455417 hasAuthorship W2004455417A5030974936 @default.
• W2004455417 hasAuthorship W2004455417A5031280081 @default.
• W2004455417 hasAuthorship W2004455417A5038654766 @default.
• W2004455417 hasAuthorship W2004455417A5049429446 @default.
• W2004455417 hasAuthorship W2004455417A5084473935 @default.
• W2004455417 hasAuthorship W2004455417A5087446373 @default.
• W2004455417 hasAuthorship W2004455417A5088897091 @default.
• W2004455417 hasConcept C10146269 @default.
• W2004455417 hasConcept C126322002 @default.
• W2004455417 hasConcept C134018914 @default.
• W2004455417 hasConcept C150903083 @default.
• W2004455417 hasConcept C16525657 @default.
• W2004455417 hasConcept C16613235 @default.
• W2004455417 hasConcept C181199279 @default.
• W2004455417 hasConcept C185592680 @default.
• W2004455417 hasConcept C187566844 @default.
• W2004455417 hasConcept C202751555 @default.
• W2004455417 hasConcept C207001950 @default.
• W2004455417 hasConcept C26291073 @default.
• W2004455417 hasConcept C2779201268 @default.
• W2004455417 hasConcept C2780408053 @default.
• W2004455417 hasConcept C2781112554 @default.
• W2004455417 hasConcept C55493867 @default.
• W2004455417 hasConcept C71924100 @default.
• W2004455417 hasConcept C86803240 @default.
• W2004455417 hasConceptScore W2004455417C10146269 @default.
• W2004455417 hasConceptScore W2004455417C126322002 @default.
• W2004455417 hasConceptScore W2004455417C134018914 @default.
• W2004455417 hasConceptScore W2004455417C150903083 @default.
• W2004455417 hasConceptScore W2004455417C16525657 @default.
• W2004455417 hasConceptScore W2004455417C16613235 @default.
• W2004455417 hasConceptScore W2004455417C181199279 @default.
• W2004455417 hasConceptScore W2004455417C185592680 @default.
• W2004455417 hasConceptScore W2004455417C187566844 @default.
• W2004455417 hasConceptScore W2004455417C202751555 @default.
• W2004455417 hasConceptScore W2004455417C207001950 @default.
• W2004455417 hasConceptScore W2004455417C26291073 @default.
• W2004455417 hasConceptScore W2004455417C2779201268 @default.
• W2004455417 hasConceptScore W2004455417C2780408053 @default.
• W2004455417 hasConceptScore W2004455417C2781112554 @default.
• W2004455417 hasConceptScore W2004455417C55493867 @default.
• W2004455417 hasConceptScore W2004455417C71924100 @default.
• W2004455417 hasConceptScore W2004455417C86803240 @default.
• W2004455417 hasIssue "5-6" @default.
• W2004455417 hasLocation W20044554171 @default.
• W2004455417 hasLocation W20044554172 @default.
• W2004455417 hasOpenAccess W2004455417 @default.

• next