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• W2004455851 abstract "The adult human cerebellum expresses melatonin receptors with high density in the external zone of the molecular layer. Cloning of the receptor cDNA isolated by RT-PCR from human cerebellar specimens and sequencing analysis of the full-length coding region revealed that the receptor protein is encoded by a transcript identical to that recently cloned from the human hypothalamus (Me1 1a ). In situ hybridization using an antisense cRNA-probe demonstrated that the melatonin receptor mRNA is localized in the cerebellar granule cells. Mapping of the messenger by RT-PCR with Me1 1a specific primers in different areas of the human brain disclosed a quite widespread distribution of the transcript, although expressed at very low levels. Semi-quantitative comparison between the different brain regions allowed to establish the following relative mRNA abundance: cerebellum ≥ occipital cortex ≥ parietal cortex > temporal cortex > thalamus > frontal cortex ≥ hippocampus. No mRNA was detected in white blood cells." @default.
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• W2004455851 date "1996-07-01" @default.
• W2004455851 modified "2023-10-16" @default.
• W2004455851 title "The melatonin receptor in the human brain: cloning experiments and distribution studies" @default.
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• W2004455851 doi "https://doi.org/10.1016/0169-328x(96)00017-4" @default.
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