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• W2004456679 abstract "Atherosclerosis results from endothelial cell dysfunction and inflammatory processes affecting both macro- and microvasculature which are involved in vascular diabetic complications. Glucagon-like peptide-1 (GLP-1) is an incretin hormone responsible for amplification of insulin secretion when nutrients are given orally as opposed to intravenously and it retains its insulinotropic activity in patients with type 2 diabetes mellitus (T2D). GLP-1 based therapies, such as GLP-1 receptor (GLP-1R) agonists and inhibitors of dipeptidyl peptidase-4, an enzyme that degrades endogenous GLP-1 are routinely used to treat patients with T2D. Recent experimental model studies have established that GLP-1R mRNA is widely expressed in several immune cells. Moreover, its activation contributes to the regulation of both thymocyte and peripheral T cells proliferation and is involved in the maintenance of peripheral regulatory T cells. GLP-1R is also expressed in endothelial and smooth muscle cells. The effect of incretin hormones on atherosclerogenesis have recently been studied in animal models of apolipoprotein E-deficient mice (apoE(-/-)). These studies have demonstrated that treatment with incretin hormones or related compounds suppresses the progression of atherosclerosis and macrophage infiltration in the arterial wall as well as a marked anti-oxidative and anti-inflammatory effect on endothelial cells. This effect may have a major impact on the attenuation of atherosclerosis and may help in the design of new therapies for cardiovascular disease in patients with type 2 diabetes." @default.
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• W2004456679 date "2012-01-01" @default.
• W2004456679 modified "2023-09-26" @default.
• W2004456679 title "Incretin hormones as immunomodulators of atherosclerosis" @default.
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• W2004456679 doi "https://doi.org/10.3389/fendo.2012.00112" @default.
• W2004456679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3435665" @default.
• W2004456679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22973260" @default.
• W2004456679 hasPublicationYear "2012" @default.
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