FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004456753> ?p ?o ?g. }

• W2004456753 endingPage "118.e6" @default.
• W2004456753 startingPage "118.e1" @default.
• W2004456753 abstract "Outcomes of Wilms tumor improved in last 50 years and excellent survival rates can be achieved especially in case of non-metastatic disease and favorable histology. Nevertheless, bilateral cases still stand as a therapeutic challenge. Prognosis of bilateral Wilms tumor (BWT) is not as good as the unilateral tumors of similar stage and histology in terms of survival and renal function.Management of BWT is constantly evolving and still stands as a therapeutic challenge. This study is designed to review and share our experiences on this topic from a surgical standpoint.The records of patients treated in our clinic between 1980 and 2013 according to Turkish Pediatric Group of Oncology protocol were analyzed retrospectively and clinical data, surgical details, pathology results, long term outcomes were analyzed.Thirteen girls and 7 boys with a mean age of 2,5 years were treated. There were 2 patients with Wilms tumor-Aniridia-Growth Retardation complex and one with isolated hemihypertrophy. Metastasis were detected in lungs of 4 patients; liver of 2 and in the cranium of one. All patients except one with the presumptive diagnosis of unilateral Wilms tumor were given preoperative chemotherapy. To sum up; 19 nephroureterectomies, 8 partial nephrectomies and 13 enucleations were performed to 36 kidneys without any major early or late postoperative complications. Pathologic results revealed positive surgical margins in 2 lesions with enucleation and in 2 with partial nephrectomies and anaplasia in 4 patients. Two patients were not operated due to parental disapproval. Two patients had the need of dialysis; one was anephric and the others' renal functions recovered over a year. Seven patients received radiotherapy for pulmonary metastasis, positive surgical margins or local recurrences. Overall, 13 patients survived and 7 died due to metastasis, recurrences, and complication of dialysis and refusal of surgical treatment. Survival among all patients was 65% and 72.2% among operated ones. Of the 7 patients with the partial nephrectomy, 2 died and 5 survived. Among enucleation group, 8 out of 10 survived and 2 died. Survival was slightly higher among enucleation group (80% vs 71.4%). Median time of follow-up for survivors of disease is 5.8 years (min: 6 months and max: 14 years).Outcomes of BWT management have changed dramatically during the last few decades from only survival, to a long life expectancy without the need of renal replacement therapy owing to improvements in treatment options. We argue that positive surgical margins do not necessarily lead to local recurrence. For this reason it may be wiser to favor on more nephron sparing surgery than to achieve negative surgical margins. Adjuvant chemotherapy and radiotherapy may be adequate to prevent local recurrence. Also, survival did not differ significantly between different ways of nephron sparing surgeries, so it may be wiser to choose enucleation over partial nephrectomy which preserves more nephrons. Nephron-sparing surgery should have utmost importance despite the risk of positive margins. On the other hand, there is not enough data to interpret if positive surgical margins have role on distant metastases or not. Presence of metastasis and recurrence seems to be an important determinant of prognosis given the fact that none of the survivors had any metastasis or recurrence.Nephron preservation should be the aim while taking positive surgical margin risk on nephron sparing surgery side relying on postoperative chemotherapy and carefully planned radiotherapy to avoid recurrence. However, there is significant diversity on the management BWT in different centers and a certain validated guideline or protocol to provide the optimal treatment is still lacking." @default.
• W2004456753 created "2016-06-24" @default.
• W2004456753 creator A5002662437 @default.
• W2004456753 creator A5006845383 @default.
• W2004456753 creator A5018470529 @default.
• W2004456753 creator A5028845775 @default.
• W2004456753 creator A5044896091 @default.
• W2004456753 creator A5048585264 @default.
• W2004456753 creator A5059238317 @default.
• W2004456753 creator A5067179038 @default.
• W2004456753 creator A5083628449 @default.
• W2004456753 date "2015-06-01" @default.
• W2004456753 modified "2023-10-16" @default.
• W2004456753 title "Management of bilateral Wilms tumor over three decades: The perspective of a single center" @default.
• W2004456753 cites W1973456821 @default.
• W2004456753 cites W1990546485 @default.
• W2004456753 cites W2000786568 @default.
• W2004456753 cites W2017955812 @default.
• W2004456753 cites W2020114416 @default.
• W2004456753 cites W2038806042 @default.
• W2004456753 cites W2049296732 @default.
• W2004456753 cites W2061972728 @default.
• W2004456753 cites W2066928433 @default.
• W2004456753 cites W2074688326 @default.
• W2004456753 cites W2077352799 @default.
• W2004456753 cites W2088654121 @default.
• W2004456753 cites W2101604399 @default.
• W2004456753 doi "https://doi.org/10.1016/j.jpurol.2014.11.012" @default.
• W2004456753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25842994" @default.
• W2004456753 hasPublicationYear "2015" @default.
• W2004456753 type Work @default.
• W2004456753 sameAs 2004456753 @default.
• W2004456753 citedByCount "16" @default.
• W2004456753 countsByYear W20044567532016 @default.
• W2004456753 countsByYear W20044567532017 @default.
• W2004456753 countsByYear W20044567532018 @default.
• W2004456753 countsByYear W20044567532021 @default.
• W2004456753 countsByYear W20044567532022 @default.
• W2004456753 countsByYear W20044567532023 @default.
• W2004456753 crossrefType "journal-article" @default.
• W2004456753 hasAuthorship W2004456753A5002662437 @default.
• W2004456753 hasAuthorship W2004456753A5006845383 @default.
• W2004456753 hasAuthorship W2004456753A5018470529 @default.
• W2004456753 hasAuthorship W2004456753A5028845775 @default.
• W2004456753 hasAuthorship W2004456753A5044896091 @default.
• W2004456753 hasAuthorship W2004456753A5048585264 @default.
• W2004456753 hasAuthorship W2004456753A5059238317 @default.
• W2004456753 hasAuthorship W2004456753A5067179038 @default.
• W2004456753 hasAuthorship W2004456753A5083628449 @default.
• W2004456753 hasConcept C104317684 @default.
• W2004456753 hasConcept C126322002 @default.
• W2004456753 hasConcept C141071460 @default.
• W2004456753 hasConcept C142724271 @default.
• W2004456753 hasConcept C146357865 @default.
• W2004456753 hasConcept C151730666 @default.
• W2004456753 hasConcept C185592680 @default.
• W2004456753 hasConcept C187212893 @default.
• W2004456753 hasConcept C2775999222 @default.
• W2004456753 hasConcept C2776608714 @default.
• W2004456753 hasConcept C2780091579 @default.
• W2004456753 hasConcept C2780227381 @default.
• W2004456753 hasConcept C2780263296 @default.
• W2004456753 hasConcept C55493867 @default.
• W2004456753 hasConcept C71924100 @default.
• W2004456753 hasConcept C86803240 @default.
• W2004456753 hasConceptScore W2004456753C104317684 @default.
• W2004456753 hasConceptScore W2004456753C126322002 @default.
• W2004456753 hasConceptScore W2004456753C141071460 @default.
• W2004456753 hasConceptScore W2004456753C142724271 @default.
• W2004456753 hasConceptScore W2004456753C146357865 @default.
• W2004456753 hasConceptScore W2004456753C151730666 @default.
• W2004456753 hasConceptScore W2004456753C185592680 @default.
• W2004456753 hasConceptScore W2004456753C187212893 @default.
• W2004456753 hasConceptScore W2004456753C2775999222 @default.
• W2004456753 hasConceptScore W2004456753C2776608714 @default.
• W2004456753 hasConceptScore W2004456753C2780091579 @default.
• W2004456753 hasConceptScore W2004456753C2780227381 @default.
• W2004456753 hasConceptScore W2004456753C2780263296 @default.
• W2004456753 hasConceptScore W2004456753C55493867 @default.
• W2004456753 hasConceptScore W2004456753C71924100 @default.
• W2004456753 hasConceptScore W2004456753C86803240 @default.
• W2004456753 hasIssue "3" @default.
• W2004456753 hasLocation W20044567531 @default.
• W2004456753 hasLocation W20044567532 @default.
• W2004456753 hasOpenAccess W2004456753 @default.
• W2004456753 hasPrimaryLocation W20044567531 @default.
• W2004456753 hasRelatedWork W1972623050 @default.
• W2004456753 hasRelatedWork W1991175447 @default.
• W2004456753 hasRelatedWork W2012119697 @default.
• W2004456753 hasRelatedWork W2021044383 @default.
• W2004456753 hasRelatedWork W2023054564 @default.
• W2004456753 hasRelatedWork W2314770128 @default.
• W2004456753 hasRelatedWork W2377200268 @default.
• W2004456753 hasRelatedWork W2412100973 @default.
• W2004456753 hasRelatedWork W2762217692 @default.
• W2004456753 hasRelatedWork W2785531090 @default.
• W2004456753 hasVolume "11" @default.
• W2004456753 isParatext "false" @default.

• next