Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004469144> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2004469144 endingPage "27" @default.
- W2004469144 startingPage "20" @default.
- W2004469144 abstract "Peptidoaminobenzophenones (1), terminal N-substituted peptidoaminobenzophenones (14), and acylglycylaminobenzophenones (16) were prepared as a novel series of ring-opened derivatives of 1,4-benzodiazepine. Z-Gly- and Z-Ala-N-methylaminobenzophenones (4) were treated with HBr-HOAc to give Gly- and Ala-N-methylaminobenzophenone hydrobromides (8). Reaction of 8 with chloroacetyl chloride in dimethylformamide (DMF) or hexamethylphosphoramide (HMPA) gave chloracetamide (13), which was allowed to react with various amines to afford a number of terminal N-substituted derivatives (14). Reaction of 8 with various acyl halides in HMPA or DMF gave a number of acylglycyl-N-methylaminobenzophenones (16). Peptidoaminobenzophenones (1) were also prepared by several convenient methods. Many of these compounds exhibited high CNS activity in animals when given orally. In antianxiety activity the potency of some compounds is equal to or higher than that of diazepam." @default.
- W2004469144 created "2016-06-24" @default.
- W2004469144 creator A5021441859 @default.
- W2004469144 creator A5036641267 @default.
- W2004469144 creator A5041540015 @default.
- W2004469144 creator A5050699355 @default.
- W2004469144 creator A5079310840 @default.
- W2004469144 creator A5089734213 @default.
- W2004469144 date "1981-01-01" @default.
- W2004469144 modified "2023-10-16" @default.
- W2004469144 title "Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl)aminobenzophenones as open-ring derivatives of benzodiazepines" @default.
- W2004469144 doi "https://doi.org/10.1021/jm00133a006" @default.
- W2004469144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6110780" @default.
- W2004469144 hasPublicationYear "1981" @default.
- W2004469144 type Work @default.
- W2004469144 sameAs 2004469144 @default.
- W2004469144 citedByCount "15" @default.
- W2004469144 countsByYear W20044691442013 @default.
- W2004469144 countsByYear W20044691442022 @default.
- W2004469144 crossrefType "journal-article" @default.
- W2004469144 hasAuthorship W2004469144A5021441859 @default.
- W2004469144 hasAuthorship W2004469144A5036641267 @default.
- W2004469144 hasAuthorship W2004469144A5041540015 @default.
- W2004469144 hasAuthorship W2004469144A5050699355 @default.
- W2004469144 hasAuthorship W2004469144A5079310840 @default.
- W2004469144 hasAuthorship W2004469144A5089734213 @default.
- W2004469144 hasConcept C155647269 @default.
- W2004469144 hasConcept C170493617 @default.
- W2004469144 hasConcept C171560689 @default.
- W2004469144 hasConcept C178790620 @default.
- W2004469144 hasConcept C185592680 @default.
- W2004469144 hasConcept C202751555 @default.
- W2004469144 hasConcept C2776175493 @default.
- W2004469144 hasConcept C2777712214 @default.
- W2004469144 hasConcept C2778006127 @default.
- W2004469144 hasConcept C2778173252 @default.
- W2004469144 hasConcept C2778695967 @default.
- W2004469144 hasConcept C2779751237 @default.
- W2004469144 hasConcept C2780378348 @default.
- W2004469144 hasConcept C2780471494 @default.
- W2004469144 hasConcept C55493867 @default.
- W2004469144 hasConcept C57992300 @default.
- W2004469144 hasConcept C71240020 @default.
- W2004469144 hasConcept C71924100 @default.
- W2004469144 hasConcept C98274493 @default.
- W2004469144 hasConceptScore W2004469144C155647269 @default.
- W2004469144 hasConceptScore W2004469144C170493617 @default.
- W2004469144 hasConceptScore W2004469144C171560689 @default.
- W2004469144 hasConceptScore W2004469144C178790620 @default.
- W2004469144 hasConceptScore W2004469144C185592680 @default.
- W2004469144 hasConceptScore W2004469144C202751555 @default.
- W2004469144 hasConceptScore W2004469144C2776175493 @default.
- W2004469144 hasConceptScore W2004469144C2777712214 @default.
- W2004469144 hasConceptScore W2004469144C2778006127 @default.
- W2004469144 hasConceptScore W2004469144C2778173252 @default.
- W2004469144 hasConceptScore W2004469144C2778695967 @default.
- W2004469144 hasConceptScore W2004469144C2779751237 @default.
- W2004469144 hasConceptScore W2004469144C2780378348 @default.
- W2004469144 hasConceptScore W2004469144C2780471494 @default.
- W2004469144 hasConceptScore W2004469144C55493867 @default.
- W2004469144 hasConceptScore W2004469144C57992300 @default.
- W2004469144 hasConceptScore W2004469144C71240020 @default.
- W2004469144 hasConceptScore W2004469144C71924100 @default.
- W2004469144 hasConceptScore W2004469144C98274493 @default.
- W2004469144 hasIssue "1" @default.
- W2004469144 hasLocation W20044691441 @default.
- W2004469144 hasLocation W20044691442 @default.
- W2004469144 hasOpenAccess W2004469144 @default.
- W2004469144 hasPrimaryLocation W20044691441 @default.
- W2004469144 hasRelatedWork W1553937913 @default.
- W2004469144 hasRelatedWork W2004469144 @default.
- W2004469144 hasRelatedWork W2014180323 @default.
- W2004469144 hasRelatedWork W2031212745 @default.
- W2004469144 hasRelatedWork W2077423963 @default.
- W2004469144 hasRelatedWork W2139985988 @default.
- W2004469144 hasRelatedWork W2420765523 @default.
- W2004469144 hasRelatedWork W2950436718 @default.
- W2004469144 hasRelatedWork W2952236365 @default.
- W2004469144 hasRelatedWork W3015795223 @default.
- W2004469144 hasVolume "24" @default.
- W2004469144 isParatext "false" @default.
- W2004469144 isRetracted "false" @default.
- W2004469144 magId "2004469144" @default.
- W2004469144 workType "article" @default.