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• W2004475101 endingPage "e76347" @default.
• W2004475101 startingPage "e76347" @default.
• W2004475101 abstract "Background Visual information is conveyed from the retina to the brain via 15–20 Retinal Ganglion Cell (RGC) types. The developmental mechanisms by which RGC types acquire their distinct molecular, morphological, physiological and circuit properties are essentially unknown, but may involve combinatorial transcriptional regulation. Brn3 transcription factors are expressed in RGCs from early developmental stages, and are restricted in adults to distinct, partially overlapping populations of RGC types. Previously, we described cell autonomous effects of Brn3b (Pou4f2) and Brn3a (Pou4f1) on RGC axon and dendrites development. Methods and Findings We now have investigated genetic interactions between Brn3 transcription factors with respect to RGC development, by crossing conventional knock-out alleles of each Brn3 gene with conditional knock-in reporter alleles of a second Brn3 gene, and analyzing the effects of single or double Brn3 knockouts on RGC survival and morphology. We find that Brn3b loss results in axon defects and dendritic arbor area and lamination defects in Brn3a positive RGCs, and selectively affects survival and morphology of specific Brn3c (Pou4f3) positive RGC types. Brn3a and Brn3b interact synergistically to control RGC numbers. Melanopsin positive ipRGCs are resistant to combined Brn3 loss but are under the transcriptional control of Isl1, expanding the combinatorial code of RGC specification. Conclusions Taken together these results complete our knowledge on the mechanisms of transcriptional control of RGC type specification. They demonstrate that Brn3b is required for the correct development of more RGC cell types than suggested by its expression pattern in the adult, but that several cell types, including some Brn3a, Brn3c or Melanopsin positive RGCs are Brn3b independent." @default.
• W2004475101 created "2016-06-24" @default.
• W2004475101 creator A5039973533 @default.
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• W2004475101 date "2013-10-08" @default.
• W2004475101 modified "2023-09-25" @default.
• W2004475101 title "Genetic Interactions between Brn3 Transcription Factors in Retinal Ganglion Cell Type Specification" @default.
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• W2004475101 doi "https://doi.org/10.1371/journal.pone.0076347" @default.
• W2004475101 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3792956" @default.
• W2004475101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24116103" @default.
• W2004475101 hasPublicationYear "2013" @default.
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