FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004476337> ?p ?o ?g. }

• W2004476337 endingPage "1065" @default.
• W2004476337 startingPage "1055" @default.
• W2004476337 abstract "Allergen-specific immunotherapy, in which repeated injections of allergens over prolonged periods are used to induce tolerance, has proven an effective treatment of allergy. A major side effect of allergen-specific immunotherapy is anaphylactic reaction. House dust mite allergens are major causative factors associated with various allergic diseases. Der f 2 is the major house dust mite allergen composed of 129 amino acid residues. Analysis using deletion mutants of Der f 2 suggested that T-cell epitopes of Der f 2 were multiple in mite-allergic patients. We found that some IgE epitopes were renatured by dialysis of a mixture of two denatured C- and N-terminal deletion mutants, 1-112 and 85-129 in 13 patients out of 14. On the other hand, IgE binding activity was negative in the separately dialyzed fragments and their mixture in each patient tested. Furthermore, we demonstrated that neither of the two separately prepared polypeptides induced in vivo skin prick test reactivity. These findings are important for improvement of T-cell targeting allergen-specific immunotherapy and development of monovalent IgE haptens. The use of combinations of overlapping non-anaphylactic fragments of allergen covering all of the T-cell epitopes achieves the removal of IgE reactivity, the cause of harmful anaphylactic reactions, without affecting the T-cell reactivity essential for immunotherapy, offering potentially safer and more effective treatment for allergic disease." @default.
• W2004476337 created "2016-06-24" @default.
• W2004476337 creator A5015488402 @default.
• W2004476337 creator A5036869700 @default.
• W2004476337 creator A5053000890 @default.
• W2004476337 creator A5065515771 @default.
• W2004476337 creator A5080139718 @default.
• W2004476337 date "1999-10-01" @default.
• W2004476337 modified "2023-09-30" @default.
• W2004476337 title "Non-anaphylactic combination of partially deleted fragments of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy" @default.
• W2004476337 cites W1487177241 @default.
• W2004476337 cites W1489911916 @default.
• W2004476337 cites W1626813947 @default.
• W2004476337 cites W1679527748 @default.
• W2004476337 cites W1758719679 @default.
• W2004476337 cites W1888308862 @default.
• W2004476337 cites W1925788296 @default.
• W2004476337 cites W1973368746 @default.
• W2004476337 cites W1974694046 @default.
• W2004476337 cites W1986124914 @default.
• W2004476337 cites W1993775186 @default.
• W2004476337 cites W2004364394 @default.
• W2004476337 cites W2009048532 @default.
• W2004476337 cites W2024249282 @default.
• W2004476337 cites W2029038234 @default.
• W2004476337 cites W2029693770 @default.
• W2004476337 cites W2035728925 @default.
• W2004476337 cites W2035847981 @default.
• W2004476337 cites W2038226520 @default.
• W2004476337 cites W2039109411 @default.
• W2004476337 cites W2039334020 @default.
• W2004476337 cites W2054079378 @default.
• W2004476337 cites W2067718690 @default.
• W2004476337 cites W2069634988 @default.
• W2004476337 cites W2074525021 @default.
• W2004476337 cites W2074639833 @default.
• W2004476337 cites W2078072837 @default.
• W2004476337 cites W2079816430 @default.
• W2004476337 cites W2081676212 @default.
• W2004476337 cites W2082543043 @default.
• W2004476337 cites W2084129498 @default.
• W2004476337 cites W2085944673 @default.
• W2004476337 cites W2087917308 @default.
• W2004476337 cites W2090687924 @default.
• W2004476337 cites W2092289268 @default.
• W2004476337 cites W2094472942 @default.
• W2004476337 cites W2109593104 @default.
• W2004476337 cites W2134889315 @default.
• W2004476337 cites W2140152586 @default.
• W2004476337 cites W2148074238 @default.
• W2004476337 cites W2155750360 @default.
• W2004476337 cites W2164025040 @default.
• W2004476337 cites W2166948911 @default.
• W2004476337 cites W2169581200 @default.
• W2004476337 cites W4234228950 @default.
• W2004476337 cites W4241394510 @default.
• W2004476337 doi "https://doi.org/10.1016/s0161-5890(99)00098-x" @default.
• W2004476337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10698308" @default.
• W2004476337 hasPublicationYear "1999" @default.
• W2004476337 type Work @default.
• W2004476337 sameAs 2004476337 @default.
• W2004476337 citedByCount "36" @default.
• W2004476337 countsByYear W20044763372012 @default.
• W2004476337 countsByYear W20044763372014 @default.
• W2004476337 countsByYear W20044763372015 @default.
• W2004476337 countsByYear W20044763372016 @default.
• W2004476337 countsByYear W20044763372017 @default.
• W2004476337 countsByYear W20044763372022 @default.
• W2004476337 crossrefType "journal-article" @default.
• W2004476337 hasAuthorship W2004476337A5015488402 @default.
• W2004476337 hasAuthorship W2004476337A5036869700 @default.
• W2004476337 hasAuthorship W2004476337A5053000890 @default.
• W2004476337 hasAuthorship W2004476337A5065515771 @default.
• W2004476337 hasAuthorship W2004476337A5080139718 @default.
• W2004476337 hasConcept C141105273 @default.
• W2004476337 hasConcept C159654299 @default.
• W2004476337 hasConcept C185592680 @default.
• W2004476337 hasConcept C195616568 @default.
• W2004476337 hasConcept C203014093 @default.
• W2004476337 hasConcept C207480886 @default.
• W2004476337 hasConcept C2775933838 @default.
• W2004476337 hasConcept C2777701055 @default.
• W2004476337 hasConcept C2778166374 @default.
• W2004476337 hasConcept C2779711295 @default.
• W2004476337 hasConcept C2780510475 @default.
• W2004476337 hasConcept C2909843257 @default.
• W2004476337 hasConcept C59822182 @default.
• W2004476337 hasConcept C71924100 @default.
• W2004476337 hasConcept C86803240 @default.
• W2004476337 hasConcept C8891405 @default.
• W2004476337 hasConceptScore W2004476337C141105273 @default.
• W2004476337 hasConceptScore W2004476337C159654299 @default.
• W2004476337 hasConceptScore W2004476337C185592680 @default.
• W2004476337 hasConceptScore W2004476337C195616568 @default.
• W2004476337 hasConceptScore W2004476337C203014093 @default.
• W2004476337 hasConceptScore W2004476337C207480886 @default.
• W2004476337 hasConceptScore W2004476337C2775933838 @default.
• W2004476337 hasConceptScore W2004476337C2777701055 @default.

• next