Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004483412> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2004483412 endingPage "1031" @default.
- W2004483412 startingPage "1028" @default.
- W2004483412 abstract "To investigate the intracellular physiology of cerebral arterial vasospasm after subarachnoid hemorrhage (SAH), we measured the activity of three protein kinases related to vascular smooth muscle function. Myosin light chain kinase (MLCK), cyclic adenosine monophosphate (cAMP)-dependent protein kinase and cyclic guanosine monophosphate (cGMP)-dependent protein kinase activity was determined in canine basilar arteries using the SAH model created by two intracisternal injections of autologous blood. Moderate chronic cerebral vasospasm was confirmed angiographically 7 days after the first injection of blood, with a mean decrease in the diameter of the basilar artery to 61.2 ± 2.3% (SE) of preinjection controls. Enzymatic analysis of basilar arteries excised from control dogs and from SAH model dogs 2 to 10 days after an intracisternal injection of blood demonstrated detectable MLCK and cyclic nucleotide-dependent protein kinase activity. The MLCK activity was approximately 3 times higher than the cyclic nucleotide-dependent protein kinase activity. There was no significant difference in basilar artery protein kinase activity between control animals and SAH model animals at any time for up to 10 days after the intracisternal injection of blood. As MLCK is involved with smooth muscle contraction and cAMP- and cGMP-dependent protein kinases are involved in smooth muscle relaxation, our results suggest that the metabolic machinery of vascular smooth muscle in the cerebral arterial wall is intact after SAH and that prolonged vasospasm represents an appropriate physiological response by the vascular smooth muscle to external stimuli. If this is correct, the successful pharmacological manipulation of vasospasm after SAH is more likely than if profound disruption had occurred, and further investigative efforts in this area should be encouraged. (Neurosurgery 22:1028-1031, 1988)" @default.
- W2004483412 created "2016-06-24" @default.
- W2004483412 creator A5006166354 @default.
- W2004483412 creator A5018258244 @default.
- W2004483412 creator A5031732733 @default.
- W2004483412 creator A5033760662 @default.
- W2004483412 creator A5036487279 @default.
- W2004483412 creator A5056721940 @default.
- W2004483412 creator A5063909273 @default.
- W2004483412 creator A5079617036 @default.
- W2004483412 date "1988-06-01" @default.
- W2004483412 modified "2023-10-16" @default.
- W2004483412 title "Protein Kinase Activity in Canine Basilar Arteries after Subarachnoid Hemorrhage" @default.
- W2004483412 doi "https://doi.org/10.1227/00006123-198806010-00009" @default.
- W2004483412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3419563" @default.
- W2004483412 hasPublicationYear "1988" @default.
- W2004483412 type Work @default.
- W2004483412 sameAs 2004483412 @default.
- W2004483412 citedByCount "23" @default.
- W2004483412 countsByYear W20044834122012 @default.
- W2004483412 countsByYear W20044834122018 @default.
- W2004483412 crossrefType "journal-article" @default.
- W2004483412 hasAuthorship W2004483412A5006166354 @default.
- W2004483412 hasAuthorship W2004483412A5018258244 @default.
- W2004483412 hasAuthorship W2004483412A5031732733 @default.
- W2004483412 hasAuthorship W2004483412A5033760662 @default.
- W2004483412 hasAuthorship W2004483412A5036487279 @default.
- W2004483412 hasAuthorship W2004483412A5056721940 @default.
- W2004483412 hasAuthorship W2004483412A5063909273 @default.
- W2004483412 hasAuthorship W2004483412A5079617036 @default.
- W2004483412 hasConcept C105702510 @default.
- W2004483412 hasConcept C126322002 @default.
- W2004483412 hasConcept C134018914 @default.
- W2004483412 hasConcept C164705383 @default.
- W2004483412 hasConcept C184235292 @default.
- W2004483412 hasConcept C2776820941 @default.
- W2004483412 hasConcept C2777736543 @default.
- W2004483412 hasConcept C2778506911 @default.
- W2004483412 hasConcept C2781012200 @default.
- W2004483412 hasConcept C55493867 @default.
- W2004483412 hasConcept C6997183 @default.
- W2004483412 hasConcept C71924100 @default.
- W2004483412 hasConcept C8035138 @default.
- W2004483412 hasConcept C86803240 @default.
- W2004483412 hasConcept C97029542 @default.
- W2004483412 hasConceptScore W2004483412C105702510 @default.
- W2004483412 hasConceptScore W2004483412C126322002 @default.
- W2004483412 hasConceptScore W2004483412C134018914 @default.
- W2004483412 hasConceptScore W2004483412C164705383 @default.
- W2004483412 hasConceptScore W2004483412C184235292 @default.
- W2004483412 hasConceptScore W2004483412C2776820941 @default.
- W2004483412 hasConceptScore W2004483412C2777736543 @default.
- W2004483412 hasConceptScore W2004483412C2778506911 @default.
- W2004483412 hasConceptScore W2004483412C2781012200 @default.
- W2004483412 hasConceptScore W2004483412C55493867 @default.
- W2004483412 hasConceptScore W2004483412C6997183 @default.
- W2004483412 hasConceptScore W2004483412C71924100 @default.
- W2004483412 hasConceptScore W2004483412C8035138 @default.
- W2004483412 hasConceptScore W2004483412C86803240 @default.
- W2004483412 hasConceptScore W2004483412C97029542 @default.
- W2004483412 hasIssue "6" @default.
- W2004483412 hasLocation W20044834121 @default.
- W2004483412 hasLocation W20044834122 @default.
- W2004483412 hasOpenAccess W2004483412 @default.
- W2004483412 hasPrimaryLocation W20044834121 @default.
- W2004483412 hasRelatedWork W1997925169 @default.
- W2004483412 hasRelatedWork W2004483412 @default.
- W2004483412 hasRelatedWork W2018028464 @default.
- W2004483412 hasRelatedWork W2104383195 @default.
- W2004483412 hasRelatedWork W2139875855 @default.
- W2004483412 hasRelatedWork W2364102773 @default.
- W2004483412 hasRelatedWork W2887148649 @default.
- W2004483412 hasRelatedWork W4200493384 @default.
- W2004483412 hasRelatedWork W4242759150 @default.
- W2004483412 hasRelatedWork W3032647944 @default.
- W2004483412 hasVolume "22" @default.
- W2004483412 isParatext "false" @default.
- W2004483412 isRetracted "false" @default.
- W2004483412 magId "2004483412" @default.
- W2004483412 workType "article" @default.